Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro

J. Clifford Murray, Lance Liotta, Stephen Israel Rennard, George R. Martin

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

We have studied the attachment of mouse fibroblasts, transformed nonmetastatic fibroblasts, and metastatic fibrosarcoma cells to various substrates. The metastatic cells attach preferentially to type IV (basement membrane) collagen in the absence of serum, compared to type I collagen and plastic. In the presence of fibronectin, these cells attach well to both type I and type IV collagens. The normal and transformed fibroblasts attach to all these substrates, although the transformed fibroblasts attach more slowly. The ability to attach to type I collagen and plastic is correlated with the levels of fibronectin and collagen produced by these cells. The data indicate that the transformed and metastatic cells differ from normal cells in their attachment properties and ability to synthesize matrix proteins. The metastatic cells possess a unique system for binding to type IV collagen that could be important in enabling these cells to penetrate tissues bounded by basement membranes. i.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalCancer Research
Volume40
Issue number2
StatePublished - Feb 1 1980

Fingerprint

Collagen Type IV
Neoplasms
Fibroblasts
Collagen Type I
Fibronectins
Plastics
In Vitro Techniques
Fibrosarcoma
Basement Membrane
Collagen
Serum
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Murray, J. C., Liotta, L., Rennard, S. I., & Martin, G. R. (1980). Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro. Cancer Research, 40(2), 347-351.

Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro. / Murray, J. Clifford; Liotta, Lance; Rennard, Stephen Israel; Martin, George R.

In: Cancer Research, Vol. 40, No. 2, 01.02.1980, p. 347-351.

Research output: Contribution to journalArticle

Murray, JC, Liotta, L, Rennard, SI & Martin, GR 1980, 'Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro', Cancer Research, vol. 40, no. 2, pp. 347-351.
Murray JC, Liotta L, Rennard SI, Martin GR. Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro. Cancer Research. 1980 Feb 1;40(2):347-351.
Murray, J. Clifford ; Liotta, Lance ; Rennard, Stephen Israel ; Martin, George R. / Adhesion Characteristics of Murine Metastatic and Nonmetastatic Tumor Cells in Vitro. In: Cancer Research. 1980 ; Vol. 40, No. 2. pp. 347-351.
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