Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy

Nina Singh, Stephen M. Berman, Susan Swindells, Janice C. Justis, Jeffrey A. Mohr, Cheryl Squier, Marilyn M. Wagener

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

The impact of demographic, psychosocial, and medical regimen-related variables on adherence of 123 human immunodeficiency virus (HIV)-infected patients to antiretroviral therapy was assessed by means of refill methodology. Satisfaction with social support (P = .029), problem-focused coping (P = .027), and active-behavioral coping (P = .011) correlated significantly with adherence, whereas loss of motivation (P = .006), hopelessness (P = .16), and avoidant coping (p = .015) correlated with nonadherence. At the 6-month follow-up, the mean CD4 cell count differed significantly among adherent versus nonadherent patients (a mean increase of 78/mm3 vs. a mean decrease of 5/mm3; P = .018). Adherence did not correlate with the number of antiretroviral medications consumed per day (mean, 3.0 vs. 2.5). Non-Caucasian patients were more likely to be nonadherent than Caucasian patients (relative risk, 2.5; 95% confidence interval, 1.2-5.3; P = .013); this difference was not explained by age, education, employment, income, history of intravenous drug use, or medical regimen. Non-Caucasian patients, however, were less satisfied with their social support (P = .04) and informational support (P = .016) and were more likely to utilize emotion- focused coping (P = .01). Thus, satisfaction with social support and coping style significantly impacted adherence and likely accounted for the observed racial difference in adherence among HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)824-830
Number of pages7
JournalClinical Infectious Diseases
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1999

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HIV
Social Support
Therapeutics
CD4 Lymphocyte Count
Motivation
Emotions
Demography
Confidence Intervals
Education
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Singh, N., Berman, S. M., Swindells, S., Justis, J. C., Mohr, J. A., Squier, C., & Wagener, M. M. (1999). Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy. Clinical Infectious Diseases, 29(4), 824-830. https://doi.org/10.1086/520443

Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy. / Singh, Nina; Berman, Stephen M.; Swindells, Susan; Justis, Janice C.; Mohr, Jeffrey A.; Squier, Cheryl; Wagener, Marilyn M.

In: Clinical Infectious Diseases, Vol. 29, No. 4, 01.01.1999, p. 824-830.

Research output: Contribution to journalArticle

Singh, N, Berman, SM, Swindells, S, Justis, JC, Mohr, JA, Squier, C & Wagener, MM 1999, 'Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy', Clinical Infectious Diseases, vol. 29, no. 4, pp. 824-830. https://doi.org/10.1086/520443
Singh, Nina ; Berman, Stephen M. ; Swindells, Susan ; Justis, Janice C. ; Mohr, Jeffrey A. ; Squier, Cheryl ; Wagener, Marilyn M. / Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy. In: Clinical Infectious Diseases. 1999 ; Vol. 29, No. 4. pp. 824-830.
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