Addition of peripheral blood stem cells collected without mobilization techniques to transplanted autologous bone marrow did not hasten marrow recovery following myeloablative therapy

F. Lobo, A. Kessinger, J. D. Landmark, D. M. Smith, D. D. Weisenburger, R. S.J.O. Wigton Armitage

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A randomized prospective trial was conducted to determine if the addition of cryopreserved autologous peripheral blood stem cells (PBSC) collected without mobilization techniques to autologous cryopreserved bone marrow for patients receiving an autologous bone marrow transplant (ABMT) affected the time to marrow function recovery. Thirty-five evaluable patients with various malignancies were studied. Sixteen received PBSC + ABMT and 19 received ABMT alone. The PBSC were collected with 4 h leukapheresis procedures on 3 consecutive days. No manipulations to increase the number of circulating stem cells were used during the collections. The median time to recover 0.5 x 109/1 circulating granulocytes was 20 days after transplantation in the ABMT group and 27 days in the PBSC + ABMT group (p = 0.12). The median time to recover 20 x 109/1 platelets was 22 days after transplantation in the ABMT group and more than 27 days in the PBSC + ABMT group (p = 0.29). The day of discharge from the hospital was earlier for the ABMT group (median 29 days) than the PBSC + ABMT group (median 35 days, p = 0.03). We did not find that the addition of non-mobilized PBSC to infused autologous marrow accelerates marrow recovery.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalBone marrow transplantation
Volume8
Issue number5
StatePublished - Jan 1 1991

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Bone Marrow
Transplants
Therapeutics
Autologous Transplantation
Peripheral Blood Stem Cells
Leukapheresis
Recovery of Function
Granulocytes
Stem Cells
Blood Platelets

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Addition of peripheral blood stem cells collected without mobilization techniques to transplanted autologous bone marrow did not hasten marrow recovery following myeloablative therapy. / Lobo, F.; Kessinger, A.; Landmark, J. D.; Smith, D. M.; Weisenburger, D. D.; Wigton Armitage, R. S.J.O.

In: Bone marrow transplantation, Vol. 8, No. 5, 01.01.1991, p. 389-392.

Research output: Contribution to journalArticle

Lobo, F. ; Kessinger, A. ; Landmark, J. D. ; Smith, D. M. ; Weisenburger, D. D. ; Wigton Armitage, R. S.J.O. / Addition of peripheral blood stem cells collected without mobilization techniques to transplanted autologous bone marrow did not hasten marrow recovery following myeloablative therapy. In: Bone marrow transplantation. 1991 ; Vol. 8, No. 5. pp. 389-392.
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