Adaptive evolution to a high purine and fat diet of carnivorans revealed by gut microbiomes and host genomes

Lifeng Zhu, Qi Wu, Cao Deng, Mengjie Zhang, Chenglin Zhang, Hua Chen, Guoqing Lu, Fuwen Wei

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Carnivorous members of the Carnivora reside at the apex of food chains and consume meat-only diets, rich in purine, fats and protein. Here, we aimed to identify potential adaptive evolutionary signatures compatible with high purine and fat metabolism based on analysis of host genomes and symbiotic gut microbial metagenomes. We found that the gut microbiomes of carnivorous Carnivora (e.g., Felidae, Canidae) clustered in the same clade, and other clades comprised omnivorous and herbivorous Carnivora (e.g., badgers, bears and pandas). The relative proportions of genes encoding enzymes involved in uric acid degradation were higher in the gut microbiomes of meat-eating carnivorans than plant-eating species. Adaptive amino acid substitutions in two enzymes, carnitine O-palmitoyltransferase 1 (CPT1A) and lipase F (LIPF), which play a role in fat digestion, were identified in Felidae-Candidae species. Carnivorous carnivorans appear to endure diets high in purines and fats via gut microbiomic and genomic adaptations.

Original languageEnglish (US)
Pages (from-to)1711-1722
Number of pages12
JournalEnvironmental microbiology
Volume20
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Carnivora
High Fat Diet
purines
fat
Felidae
genome
digestive system
Fats
Genome
diet
lipids
ingestion
meat
Meat
carnitine palmitoyltransferase
badgers
Canidae
Eating
Metagenome
amino acid substitution

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Adaptive evolution to a high purine and fat diet of carnivorans revealed by gut microbiomes and host genomes. / Zhu, Lifeng; Wu, Qi; Deng, Cao; Zhang, Mengjie; Zhang, Chenglin; Chen, Hua; Lu, Guoqing; Wei, Fuwen.

In: Environmental microbiology, Vol. 20, No. 5, 01.05.2018, p. 1711-1722.

Research output: Contribution to journalArticle

Zhu, Lifeng ; Wu, Qi ; Deng, Cao ; Zhang, Mengjie ; Zhang, Chenglin ; Chen, Hua ; Lu, Guoqing ; Wei, Fuwen. / Adaptive evolution to a high purine and fat diet of carnivorans revealed by gut microbiomes and host genomes. In: Environmental microbiology. 2018 ; Vol. 20, No. 5. pp. 1711-1722.
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