Adaptive changes in the neuromagnetic response of the primary and association somatosensory areas following repetitive tactile hand stimulation in humans

Elena Anda Popescu, Steven M Barlow, Lalit Venkatesan, Jingyan Wang, Mihai Popescu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cortical adaptation in the primary somatosensory cortex (SI) has been probed using different stimulation modalities and recording techniques, in both human and animal studies. In contrast, considerably less knowledge has been gained about the adaptation profiles in other areas of the cortical somatosensory network. Using magnetoencephalography (MEG), we examined the patterns of short-term adaptation for evoked responses in SI and somatosensory association areas during tactile stimulation applied to the glabrous skin of the hand. Cutaneous stimuli were delivered as trains of serial pulses with a constant frequency of 2 Hz and 4 Hz in separate runs, and a constant inter-train interval of 5 s. The unilateral stimuli elicited transient responses to the serial pulses in the train, with several response components that were separated by independent component analysis. Subsequent source reconstruction techniques identified regional generators in the contralateral SI and somatosensory association areas in the posterior parietal cortex (PPC). Activity in the bilateral secondary somatosensory cortex (i.e., SII/PV) was also identified, although less consistently across subjects. The dynamics of the evoked activity in each area and the frequency-dependent adaptation effects were assessed from the changes in the relative amplitude of serial responses in each train. We show that the adaptation profiles in SI and PPC areas can be quantitatively characterized from neuromagnetic recordings using tactile stimulation, with the sensitivity to repetitive stimulation increasing from SI to PPC. A similar approach for SII/PV has proven less straightforward, potentially due to the tendency of these areas to respond selectively to certain stimuli.

Original languageEnglish (US)
Pages (from-to)1415-1426
Number of pages12
JournalHuman Brain Mapping
Volume34
Issue number6
DOIs
StatePublished - Jun 1 2013

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Parietal Lobe
Somatosensory Cortex
Touch
Hand
Magnetoencephalography
Skin

Keywords

  • Cortical adaptation
  • Magnetoencephalography (MEG)
  • Primary somatosensory cortex
  • Somatosensory association areas
  • Tactile stimulation

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Adaptive changes in the neuromagnetic response of the primary and association somatosensory areas following repetitive tactile hand stimulation in humans. / Popescu, Elena Anda; Barlow, Steven M; Venkatesan, Lalit; Wang, Jingyan; Popescu, Mihai.

In: Human Brain Mapping, Vol. 34, No. 6, 01.06.2013, p. 1415-1426.

Research output: Contribution to journalArticle

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