Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons

Russell L. Snyder, Donal G. Sinex, Joann D. McGee, Edward W. Walsh

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Many studies have reported plastic changes in central auditory frequency organization after chronic cochlear lesions. These studies employed mechanical, acoustic or drug-induced disruptions of restricted regions of the organ of Corti that permanently alter its tuning and sensitivity and require an extended recovery period before central effects can be measured. In this study, mechanical lesions were made to 1 mm sectors of the spiral ganglion (SG). These lesions remove a restricted portion of the cochlear output, but leave the organ of Corti and basilar membrane intact. Multiunit mapping assessed the pre- and post-lesion tonotopic organization of the inferior colliculus (IC). Immediately after SG lesions, IC neurons previously tuned to the lesion frequencies became less sensitive to those frequencies but more sensitive to lesion edge frequencies, resulting in a shift in their characteristic frequencies (CFs). Notches in the excitatory response areas at frequencies corresponding to the lesion frequencies and expansion of spatial tuning curves were also observed. CFs of neurons tuned to unlesioned frequencies were unchanged. These results suggest that 'plastic' changes similar to those observed after long survival times in previous studies require little or no experience and occur within minutes to hours following the lesion. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)200-220
Number of pages21
JournalHearing Research
Volume147
Issue number1-2
DOIs
StatePublished - Sep 1 2000

Fingerprint

Spiral Ganglion
Organ of Corti
Inferior Colliculi
Cochlea
Cats
Basilar Membrane
Neurons
Acoustics
Plastics
Pharmaceutical Preparations

Keywords

  • Cochlear lesion
  • Hearing loss
  • Inferior colliculus
  • Plasticity
  • Tonotopic reorganization

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons. / Snyder, Russell L.; Sinex, Donal G.; McGee, Joann D.; Walsh, Edward W.

In: Hearing Research, Vol. 147, No. 1-2, 01.09.2000, p. 200-220.

Research output: Contribution to journalArticle

Snyder, Russell L. ; Sinex, Donal G. ; McGee, Joann D. ; Walsh, Edward W. / Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons. In: Hearing Research. 2000 ; Vol. 147, No. 1-2. pp. 200-220.
@article{ab17462d9409452d80727f587727beda,
title = "Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons",
abstract = "Many studies have reported plastic changes in central auditory frequency organization after chronic cochlear lesions. These studies employed mechanical, acoustic or drug-induced disruptions of restricted regions of the organ of Corti that permanently alter its tuning and sensitivity and require an extended recovery period before central effects can be measured. In this study, mechanical lesions were made to 1 mm sectors of the spiral ganglion (SG). These lesions remove a restricted portion of the cochlear output, but leave the organ of Corti and basilar membrane intact. Multiunit mapping assessed the pre- and post-lesion tonotopic organization of the inferior colliculus (IC). Immediately after SG lesions, IC neurons previously tuned to the lesion frequencies became less sensitive to those frequencies but more sensitive to lesion edge frequencies, resulting in a shift in their characteristic frequencies (CFs). Notches in the excitatory response areas at frequencies corresponding to the lesion frequencies and expansion of spatial tuning curves were also observed. CFs of neurons tuned to unlesioned frequencies were unchanged. These results suggest that 'plastic' changes similar to those observed after long survival times in previous studies require little or no experience and occur within minutes to hours following the lesion. (C) 2000 Elsevier Science B.V.",
keywords = "Cochlear lesion, Hearing loss, Inferior colliculus, Plasticity, Tonotopic reorganization",
author = "Snyder, {Russell L.} and Sinex, {Donal G.} and McGee, {Joann D.} and Walsh, {Edward W.}",
year = "2000",
month = "9",
day = "1",
doi = "10.1016/S0378-5955(00)00132-5",
language = "English (US)",
volume = "147",
pages = "200--220",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons

AU - Snyder, Russell L.

AU - Sinex, Donal G.

AU - McGee, Joann D.

AU - Walsh, Edward W.

PY - 2000/9/1

Y1 - 2000/9/1

N2 - Many studies have reported plastic changes in central auditory frequency organization after chronic cochlear lesions. These studies employed mechanical, acoustic or drug-induced disruptions of restricted regions of the organ of Corti that permanently alter its tuning and sensitivity and require an extended recovery period before central effects can be measured. In this study, mechanical lesions were made to 1 mm sectors of the spiral ganglion (SG). These lesions remove a restricted portion of the cochlear output, but leave the organ of Corti and basilar membrane intact. Multiunit mapping assessed the pre- and post-lesion tonotopic organization of the inferior colliculus (IC). Immediately after SG lesions, IC neurons previously tuned to the lesion frequencies became less sensitive to those frequencies but more sensitive to lesion edge frequencies, resulting in a shift in their characteristic frequencies (CFs). Notches in the excitatory response areas at frequencies corresponding to the lesion frequencies and expansion of spatial tuning curves were also observed. CFs of neurons tuned to unlesioned frequencies were unchanged. These results suggest that 'plastic' changes similar to those observed after long survival times in previous studies require little or no experience and occur within minutes to hours following the lesion. (C) 2000 Elsevier Science B.V.

AB - Many studies have reported plastic changes in central auditory frequency organization after chronic cochlear lesions. These studies employed mechanical, acoustic or drug-induced disruptions of restricted regions of the organ of Corti that permanently alter its tuning and sensitivity and require an extended recovery period before central effects can be measured. In this study, mechanical lesions were made to 1 mm sectors of the spiral ganglion (SG). These lesions remove a restricted portion of the cochlear output, but leave the organ of Corti and basilar membrane intact. Multiunit mapping assessed the pre- and post-lesion tonotopic organization of the inferior colliculus (IC). Immediately after SG lesions, IC neurons previously tuned to the lesion frequencies became less sensitive to those frequencies but more sensitive to lesion edge frequencies, resulting in a shift in their characteristic frequencies (CFs). Notches in the excitatory response areas at frequencies corresponding to the lesion frequencies and expansion of spatial tuning curves were also observed. CFs of neurons tuned to unlesioned frequencies were unchanged. These results suggest that 'plastic' changes similar to those observed after long survival times in previous studies require little or no experience and occur within minutes to hours following the lesion. (C) 2000 Elsevier Science B.V.

KW - Cochlear lesion

KW - Hearing loss

KW - Inferior colliculus

KW - Plasticity

KW - Tonotopic reorganization

UR - http://www.scopus.com/inward/record.url?scp=0033842185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033842185&partnerID=8YFLogxK

U2 - 10.1016/S0378-5955(00)00132-5

DO - 10.1016/S0378-5955(00)00132-5

M3 - Article

VL - 147

SP - 200

EP - 220

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

IS - 1-2

ER -