Acute renal failure: Unusual complication of Epstein-Barr virus-induced infectious mononucleosis

Paul S. Lei, Amy Lowichik, Wain Allen, Teri Jo Mauch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.

Original languageEnglish (US)
Pages (from-to)1519-1524
Number of pages6
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume31
Issue number6
DOIs
StatePublished - Dec 2000

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Interstitial Nephritis
Infectious Mononucleosis
Juvenile Arthritis
Hemolytic Anemia
Methylprednisolone
Jaundice
Cell Nucleus
Human Herpesvirus 4
Acute Kidney Injury
Thrombocytopenia
T-Lymphocytes
Kidney
Biopsy
Messenger RNA
Therapeutics
Epstein-Barr virus encoded RNA 1

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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abstract = "A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.",
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