Acute Radiation Injury

Contingency Planning for Triage, Supportive Care, and Transplantation

Daniel Weisdorf, Nelson Chao, Jamie K. Waselenko, Nicholas Dainiak, James Olen Armitage, Ian McNiece, Dennis Confer

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Evaluation and management of victims of exposure to myelosuppressive radiation in a military, terrorist, or accidental event is challenging. The hematopoietic syndrome with marrow suppression and pancytopenia follows intermediate intensity radiation exposure and as such produces a clinical syndrome similar to that after myelosuppressive chemotherapy or stem cell transplantation. Therefore, hematologists, oncologists, and transplantation physicians have the opportunity and challenge to plan for care of irradiation victims. Management of the hematopoietic syndrome, as a component of acute radiation sickness, requires understanding its manifestations and implementation of clinical biodosimetry to provide appropriate therapeutic support. Hematopoietic growth factors may be of value if administered early as a component of supportive care. Planning for urgent stem cell transplantation for those with intermediate- to high-dose radiation (4-10 Gy) may be required. Establishing contingency plans for triage, assessment, supportive care, and treatment resembles the development of phase II trials, with defined eligibilities, treatment plans, and incorporated data collection to assess results and plan further improvements in care. The hematology/oncology community is most suited to participate in such contingency planning, and the necessary elements for its success are reviewed.

Original languageEnglish (US)
Pages (from-to)672-682
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2006

Fingerprint

Radiation Injuries
Triage
Transplantation
Stem Cell Transplantation
Radiation
Pancytopenia
Hematology
Intercellular Signaling Peptides and Proteins
Therapeutics
Bone Marrow
Physicians
Drug Therapy

Keywords

  • Contingency planning
  • Radiation injury
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Acute Radiation Injury : Contingency Planning for Triage, Supportive Care, and Transplantation. / Weisdorf, Daniel; Chao, Nelson; Waselenko, Jamie K.; Dainiak, Nicholas; Armitage, James Olen; McNiece, Ian; Confer, Dennis.

In: Biology of Blood and Marrow Transplantation, Vol. 12, No. 6, 01.06.2006, p. 672-682.

Research output: Contribution to journalArticle

Weisdorf, Daniel ; Chao, Nelson ; Waselenko, Jamie K. ; Dainiak, Nicholas ; Armitage, James Olen ; McNiece, Ian ; Confer, Dennis. / Acute Radiation Injury : Contingency Planning for Triage, Supportive Care, and Transplantation. In: Biology of Blood and Marrow Transplantation. 2006 ; Vol. 12, No. 6. pp. 672-682.
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