Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1

D. S. Harrington, C. Peterson, M. Ness, Warren G Sanger, D. M. Smith, W. Vaughan

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

A 50-year-old woman presented with anemia and eosinophilia. Her bone marrow biopsy, peripheral blood, and clinical features were consistent with a diagnosis of an evolving acute myelogenous leukemia. Striking dysplastic eosinophilic differentiation associated with trisomy-1 was evident, and eosinophil granule major basic protein was detected in involved tissue. Trisomy-1 has not been previously reported in association with acute myelogenous leukemia showing eosinophilic differentiation. Intensive cytotoxic chemotherapy produced a short-lived clinical and cytogenetic remission. At autopsy multiple tumor nodules composed of dysplastic eosinophil precursors and myeloblasts were evident in multiple organs.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalAmerican journal of clinical pathology
Volume90
Issue number4
DOIs
StatePublished - Jan 1 1988

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Trisomy
Acute Myeloid Leukemia
Eosinophil Major Basic Protein
Granulocyte Precursor Cells
Eosinophilia
Eosinophils
Cytogenetics
Anemia
Autopsy
Bone Marrow
Biopsy
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Harrington, D. S., Peterson, C., Ness, M., Sanger, W. G., Smith, D. M., & Vaughan, W. (1988). Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1. American journal of clinical pathology, 90(4), 464-469. https://doi.org/10.1093/ajcp/90.4.464

Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1. / Harrington, D. S.; Peterson, C.; Ness, M.; Sanger, Warren G; Smith, D. M.; Vaughan, W.

In: American journal of clinical pathology, Vol. 90, No. 4, 01.01.1988, p. 464-469.

Research output: Contribution to journalReview article

Harrington, DS, Peterson, C, Ness, M, Sanger, WG, Smith, DM & Vaughan, W 1988, 'Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1', American journal of clinical pathology, vol. 90, no. 4, pp. 464-469. https://doi.org/10.1093/ajcp/90.4.464
Harrington, D. S. ; Peterson, C. ; Ness, M. ; Sanger, Warren G ; Smith, D. M. ; Vaughan, W. / Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1. In: American journal of clinical pathology. 1988 ; Vol. 90, No. 4. pp. 464-469.
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