Abstract

Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.

Original languageEnglish (US)
Pages (from-to)735-743
Number of pages9
JournalLeukemia Research
Volume13
Issue number9
DOIs
StatePublished - Jan 1 1989

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Cell Lineage
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Natural Killer Cells
Interleukin-2
Bone Marrow
Phenotype
Neoplasms

Keywords

  • Acute lymphoblastic leukemia
  • CD11b
  • CD8
  • interleukin 2
  • natural killer cell
  • phenotype

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Acute lymphoblastic leukemia of NK-cell lineage : Responses to IL-2. / Pirruccello, Samuel Jay; Bicak, Molly S.; Gordon, Bruce Geoffrey; Gajl-Peczalska, Kazimiera; Gnarra, David J.; Coccia, Peter F.

In: Leukemia Research, Vol. 13, No. 9, 01.01.1989, p. 735-743.

Research output: Contribution to journalArticle

Pirruccello, Samuel Jay ; Bicak, Molly S. ; Gordon, Bruce Geoffrey ; Gajl-Peczalska, Kazimiera ; Gnarra, David J. ; Coccia, Peter F. / Acute lymphoblastic leukemia of NK-cell lineage : Responses to IL-2. In: Leukemia Research. 1989 ; Vol. 13, No. 9. pp. 735-743.
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