Acute inflammatory demyelinating polyneuropathy

Contribution of a dispersed distal compound muscle action potential to electrodiagnosis

James C. Cleland, Khizar Malik, Pariwat Thaisetthawatkul, David N. Herrmann, Eric L. Logigian

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Prolonged duration of the distal compound muscle action potential (DCMAP) ("DCMAP dispersion") is useful in the electrodiagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) with good specificity in distinguishing CIDP from amyotrophic lateral sclerosis (ALS) and diabetic polyneuropathy, but its role in the electrodiagnosis of acute inflammatory demyelinating polyneuropathy (AIDP) is unclear. This study addresses this issue by determining the optimal cutoff for DCMAP duration using receiver operating characteristic (ROC) analysis in 207 motor nerves from 53 clinically defined AIDP patients compared to 148 motor nerves from 55 ALS patients. We also determined whether the presence of DCMAP dispersion improves the sensitivity of four of the most sensitive published sets of electrodiagnostic criteria for AIDP. Using the ROC-derived optimal DCMAP duration cutoff of 8.5 ms, DCMAP dispersion was found in at least one motor nerve in 66% of subjects with AIDP compared to 9% of subjects with ALS. DCMAP dispersion improved the sensitivity of the four tested criteria sets to 76%-87% from 43%-77%. Moreover, of 13 AIDP patients who met none of the four published criteria sets, 5 (38%) had at least one dispersed DCMAP. These findings indicate that the presence of DCMAP dispersion adds electrodiagnostic sensitivity to the currently published criteria sets, while maintaining reasonably high specificity against a prototypical disorder of the primary motor neuron with axon loss.

Original languageEnglish (US)
Pages (from-to)771-777
Number of pages7
JournalMuscle and Nerve
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2006

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Electrodiagnosis
Guillain-Barre Syndrome
Action Potentials
Muscles
Amyotrophic Lateral Sclerosis
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
ROC Curve
Diabetic Neuropathies
Motor Neurons
Axons

Keywords

  • Acute inflammatory demyelinating polyneuropathy
  • Compound muscle action potential
  • Electrodiagnostic criteria
  • Temporal dispersion

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Acute inflammatory demyelinating polyneuropathy : Contribution of a dispersed distal compound muscle action potential to electrodiagnosis. / Cleland, James C.; Malik, Khizar; Thaisetthawatkul, Pariwat; Herrmann, David N.; Logigian, Eric L.

In: Muscle and Nerve, Vol. 33, No. 6, 01.06.2006, p. 771-777.

Research output: Contribution to journalArticle

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