Acute graft-versus-host disease resulting from normal donor blood transfusions1

Linda J. Burns, Mark W. Westberg, C. Patrick Burns, Lynell Warren Klassen, Nancy E. Goeken, Thomas L. Ray, Donald E. Macfarlane

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin's disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal donors are also reviewed. It should be suspected when fever or rash appear 1-2 weeks after transfusion of unirradiated blood products into a compromised host or when pancyto-penia following chemotherapy is prolonged or unexpectedly severe. Prevention of GvHD by irradiation of granulocytes, platelets and packed red blood cells given to im-munosuppressed patients is recommended to prevent this often fatal disease.

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalActa Haematologica
Volume71
Issue number4
DOIs
StatePublished - Jan 1 1984

Fingerprint

Graft vs Host Disease
Blood Donors
Blood Transfusion
Drug Therapy
Histocompatibility Testing
Exanthema
Hodgkin Disease
Granulocytes
Fever
Blood Platelets
Erythrocytes
Tissue Donors
Biopsy
Skin

Keywords

  • Graft-versus-host disease
  • Transfusions

ASJC Scopus subject areas

  • Hematology

Cite this

Burns, L. J., Westberg, M. W., Patrick Burns, C., Klassen, L. W., Goeken, N. E., Ray, T. L., & Macfarlane, D. E. (1984). Acute graft-versus-host disease resulting from normal donor blood transfusions1 Acta Haematologica, 71(4), 270-276. https://doi.org/10.1159/000206599

Acute graft-versus-host disease resulting from normal donor blood transfusions1 . / Burns, Linda J.; Westberg, Mark W.; Patrick Burns, C.; Klassen, Lynell Warren; Goeken, Nancy E.; Ray, Thomas L.; Macfarlane, Donald E.

In: Acta Haematologica, Vol. 71, No. 4, 01.01.1984, p. 270-276.

Research output: Contribution to journalArticle

Burns, LJ, Westberg, MW, Patrick Burns, C, Klassen, LW, Goeken, NE, Ray, TL & Macfarlane, DE 1984, 'Acute graft-versus-host disease resulting from normal donor blood transfusions1 ', Acta Haematologica, vol. 71, no. 4, pp. 270-276. https://doi.org/10.1159/000206599
Burns, Linda J. ; Westberg, Mark W. ; Patrick Burns, C. ; Klassen, Lynell Warren ; Goeken, Nancy E. ; Ray, Thomas L. ; Macfarlane, Donald E. / Acute graft-versus-host disease resulting from normal donor blood transfusions1 In: Acta Haematologica. 1984 ; Vol. 71, No. 4. pp. 270-276.
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