Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes

James T. Lane, Carol B Toris, Samer N. Nakhle, David M. Chacko, Yun Liang Wang, Michael E. Yablonski

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: Previous studies reported reduced aqueous humor flow through the anterior segment of the eye in patients with type 1 diabetes. This study investigates whether reduced flow is the result of the diabetic state or of alterations in glucose or insulin concentrations. METHODS: A cross-sectional study, involving patients with type 1 diabetes and healthy controls, measured aqueous flow at different insulin concentrations. Eleven patients with type 1 diabetes (hemoglobin A1C = 7.0 ± 0.3% [mean ± SEM], normal < 6.5) with no microvascular complications and 17 controls were prospectively studied. Controls were studied fasting and during a hyperinsulinemic-euglycemic clamp (insulin 2 mU/kg per minute). Patients with type 1 diabetes were similarly studied during two euglycemic clamp procedures (insulin 0.5 and 2.0 mU/kg per minute). Aqueous flow was measured by fluorophotometry. Pulsatile ocular blood flow and intraocular pressure were measured with a Langham flow probe. RESULTS: Control subjects had no change in aqueous flow during fasting and hyperinsulinemic conditions (3.0 ± 0.1 vs 2.8 ± 0.1 μl per minute). In the patients with type 1 diabetes, aqueous flow was not decreased with hyperinsulinemia, compared with the low insulin state (P = .7). Compared with control subjects, patients with type 1 diabetes had lower aqueous flow during hyperinsulinemia (2.4 ± 0.1 μl per minute, P = .03) and at lower insulin conditions (2.6 ± 0.1 μl per minute, P < .05). No differences in intraocular pressure or pulsatile ocular blood flow were noted between groups or between insulin states within groups. CONCLUSIONS: Aqueous flow is decreased in patients with type 1 diabetes under euglycemic conditions of high and relatively low insulin concentrations, despite the absence of microvascular complications.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalAmerican journal of ophthalmology
Volume132
Issue number3
DOIs
StatePublished - Aug 31 2001

Fingerprint

Aqueous Humor
Type 1 Diabetes Mellitus
Insulin
Glucose Clamp Technique
Hyperinsulinism
Intraocular Pressure
Fasting
Fluorophotometry
Anterior Eye Segment
Hemoglobins
Cross-Sectional Studies
Blood Pressure
Glucose

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes. / Lane, James T.; Toris, Carol B; Nakhle, Samer N.; Chacko, David M.; Wang, Yun Liang; Yablonski, Michael E.

In: American journal of ophthalmology, Vol. 132, No. 3, 31.08.2001, p. 321-327.

Research output: Contribution to journalArticle

Lane, James T. ; Toris, Carol B ; Nakhle, Samer N. ; Chacko, David M. ; Wang, Yun Liang ; Yablonski, Michael E. / Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes. In: American journal of ophthalmology. 2001 ; Vol. 132, No. 3. pp. 321-327.
@article{692d098f564d4413aa559c3ba505a9a7,
title = "Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes",
abstract = "PURPOSE: Previous studies reported reduced aqueous humor flow through the anterior segment of the eye in patients with type 1 diabetes. This study investigates whether reduced flow is the result of the diabetic state or of alterations in glucose or insulin concentrations. METHODS: A cross-sectional study, involving patients with type 1 diabetes and healthy controls, measured aqueous flow at different insulin concentrations. Eleven patients with type 1 diabetes (hemoglobin A1C = 7.0 ± 0.3{\%} [mean ± SEM], normal < 6.5) with no microvascular complications and 17 controls were prospectively studied. Controls were studied fasting and during a hyperinsulinemic-euglycemic clamp (insulin 2 mU/kg per minute). Patients with type 1 diabetes were similarly studied during two euglycemic clamp procedures (insulin 0.5 and 2.0 mU/kg per minute). Aqueous flow was measured by fluorophotometry. Pulsatile ocular blood flow and intraocular pressure were measured with a Langham flow probe. RESULTS: Control subjects had no change in aqueous flow during fasting and hyperinsulinemic conditions (3.0 ± 0.1 vs 2.8 ± 0.1 μl per minute). In the patients with type 1 diabetes, aqueous flow was not decreased with hyperinsulinemia, compared with the low insulin state (P = .7). Compared with control subjects, patients with type 1 diabetes had lower aqueous flow during hyperinsulinemia (2.4 ± 0.1 μl per minute, P = .03) and at lower insulin conditions (2.6 ± 0.1 μl per minute, P < .05). No differences in intraocular pressure or pulsatile ocular blood flow were noted between groups or between insulin states within groups. CONCLUSIONS: Aqueous flow is decreased in patients with type 1 diabetes under euglycemic conditions of high and relatively low insulin concentrations, despite the absence of microvascular complications.",
author = "Lane, {James T.} and Toris, {Carol B} and Nakhle, {Samer N.} and Chacko, {David M.} and Wang, {Yun Liang} and Yablonski, {Michael E.}",
year = "2001",
month = "8",
day = "31",
doi = "10.1016/S0002-9394(01)01048-0",
language = "English (US)",
volume = "132",
pages = "321--327",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes

AU - Lane, James T.

AU - Toris, Carol B

AU - Nakhle, Samer N.

AU - Chacko, David M.

AU - Wang, Yun Liang

AU - Yablonski, Michael E.

PY - 2001/8/31

Y1 - 2001/8/31

N2 - PURPOSE: Previous studies reported reduced aqueous humor flow through the anterior segment of the eye in patients with type 1 diabetes. This study investigates whether reduced flow is the result of the diabetic state or of alterations in glucose or insulin concentrations. METHODS: A cross-sectional study, involving patients with type 1 diabetes and healthy controls, measured aqueous flow at different insulin concentrations. Eleven patients with type 1 diabetes (hemoglobin A1C = 7.0 ± 0.3% [mean ± SEM], normal < 6.5) with no microvascular complications and 17 controls were prospectively studied. Controls were studied fasting and during a hyperinsulinemic-euglycemic clamp (insulin 2 mU/kg per minute). Patients with type 1 diabetes were similarly studied during two euglycemic clamp procedures (insulin 0.5 and 2.0 mU/kg per minute). Aqueous flow was measured by fluorophotometry. Pulsatile ocular blood flow and intraocular pressure were measured with a Langham flow probe. RESULTS: Control subjects had no change in aqueous flow during fasting and hyperinsulinemic conditions (3.0 ± 0.1 vs 2.8 ± 0.1 μl per minute). In the patients with type 1 diabetes, aqueous flow was not decreased with hyperinsulinemia, compared with the low insulin state (P = .7). Compared with control subjects, patients with type 1 diabetes had lower aqueous flow during hyperinsulinemia (2.4 ± 0.1 μl per minute, P = .03) and at lower insulin conditions (2.6 ± 0.1 μl per minute, P < .05). No differences in intraocular pressure or pulsatile ocular blood flow were noted between groups or between insulin states within groups. CONCLUSIONS: Aqueous flow is decreased in patients with type 1 diabetes under euglycemic conditions of high and relatively low insulin concentrations, despite the absence of microvascular complications.

AB - PURPOSE: Previous studies reported reduced aqueous humor flow through the anterior segment of the eye in patients with type 1 diabetes. This study investigates whether reduced flow is the result of the diabetic state or of alterations in glucose or insulin concentrations. METHODS: A cross-sectional study, involving patients with type 1 diabetes and healthy controls, measured aqueous flow at different insulin concentrations. Eleven patients with type 1 diabetes (hemoglobin A1C = 7.0 ± 0.3% [mean ± SEM], normal < 6.5) with no microvascular complications and 17 controls were prospectively studied. Controls were studied fasting and during a hyperinsulinemic-euglycemic clamp (insulin 2 mU/kg per minute). Patients with type 1 diabetes were similarly studied during two euglycemic clamp procedures (insulin 0.5 and 2.0 mU/kg per minute). Aqueous flow was measured by fluorophotometry. Pulsatile ocular blood flow and intraocular pressure were measured with a Langham flow probe. RESULTS: Control subjects had no change in aqueous flow during fasting and hyperinsulinemic conditions (3.0 ± 0.1 vs 2.8 ± 0.1 μl per minute). In the patients with type 1 diabetes, aqueous flow was not decreased with hyperinsulinemia, compared with the low insulin state (P = .7). Compared with control subjects, patients with type 1 diabetes had lower aqueous flow during hyperinsulinemia (2.4 ± 0.1 μl per minute, P = .03) and at lower insulin conditions (2.6 ± 0.1 μl per minute, P < .05). No differences in intraocular pressure or pulsatile ocular blood flow were noted between groups or between insulin states within groups. CONCLUSIONS: Aqueous flow is decreased in patients with type 1 diabetes under euglycemic conditions of high and relatively low insulin concentrations, despite the absence of microvascular complications.

UR - http://www.scopus.com/inward/record.url?scp=0034886031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034886031&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(01)01048-0

DO - 10.1016/S0002-9394(01)01048-0

M3 - Article

C2 - 11530043

AN - SCOPUS:0034886031

VL - 132

SP - 321

EP - 327

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -