Activity of diimidazoline amides against African trypanosomiasis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but none was as effective as the latter in a T. brucei rhodesiense-infected mouse model. A single imidazoline may be sufficient for high antitrypanosomal activity provided that a second weak base functional group is present.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number3
DOIs
StatePublished - Feb 1 2014

Fingerprint

Trypanosoma brucei rhodesiense
African Trypanosomiasis
Pentamidine
Amides
Diamide
Imidazolines
Functional groups

Keywords

  • African trypanosomiasis
  • Diimidazoline
  • Trypanosoma brucei rhodesiense

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Activity of diimidazoline amides against African trypanosomiasis. / Dong, Yuxiang; Wang, Xiaofang; Cal, Monica; Kaiser, Marcel; Vennerstrom, Jonathan L.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 3, 01.02.2014, p. 944-948.

Research output: Contribution to journalArticle

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