Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions

Melanie L. Langford, Sahar Hasim, Kenneth Nickerson, Audrey L Atkin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Farnesol interacts with Candida albicans as both a quorum-sensing molecule and toxic agent, but confusion abounds regarding which conditions promote these distinct responses. Farnesol sensitivity was measured when inoculum cell history and size, temperature, and growth media were altered. Parameters for farnesol tolerance/ sensitivity were defined, validating previous studies and identifying new variables, such as energy availability. This study clearly defines what farnesol concentrations are lethal to C. albicans, based on environmental conditions.

Original languageEnglish (US)
Pages (from-to)940-942
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Farnesol
Candida albicans
Growth
Quorum Sensing
Poisons
Cell Size
History
Temperature

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. / Langford, Melanie L.; Hasim, Sahar; Nickerson, Kenneth; Atkin, Audrey L.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 2, 01.02.2010, p. 940-942.

Research output: Contribution to journalArticle

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