Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion

Shu Tao, G. Calza, F. Lerzo, A. Virgone, N. Camassa, G. Panizzon, A. Bertolini, L. Brunelli, R. Moretti, P. Grasso, gm Ghiggeri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The glutathione (GSH) system is the main defence of tissues against free radicals and red blood cells (RBC) are the most efficient sites for GSH redox cycle activation. Total GSH was assayed during cardiopulmonary bypass (CPB) in RBC and serum from the coronary sinus, peripheral arteries and veins in 18 children corrected of their cardiac defect. Our conclusions are: (1) RBC-GSH redox cycle is activated during heart ischaemia and reperfusion; (2) the activation of intracellular GSH system is preponderant compared with the extracellular one; (3) variations in intraerythrocytic total GSH during heart ischaemia and perfusion are detectable in peripheral veins and arteries, which can be the convenient sites for monitoring changes in the GSH cycle; and (4) increased total GSH levels are present in RBC before aortic crossclamping: at the beginning of mechanical ventilation in veins and, when CPB is started, also in arteries.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalPerfusion
Volume10
Issue number1
DOIs
StatePublished - Jan 1995

Fingerprint

Cardiopulmonary Bypass
activation
Glutathione
Blood
Perfusion
Erythrocytes
Chemical activation
Veins
Arteries
Oxidation-Reduction
Ischemia
monitoring
Coronary Sinus
Free radicals
Artificial Respiration
Reperfusion
Free Radicals
Cells
Tissue
Defects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion. / Tao, Shu; Calza, G.; Lerzo, F.; Virgone, A.; Camassa, N.; Panizzon, G.; Bertolini, A.; Brunelli, L.; Moretti, R.; Grasso, P.; Ghiggeri, gm.

In: Perfusion, Vol. 10, No. 1, 01.1995, p. 45-50.

Research output: Contribution to journalArticle

Tao, S, Calza, G, Lerzo, F, Virgone, A, Camassa, N, Panizzon, G, Bertolini, A, Brunelli, L, Moretti, R, Grasso, P & Ghiggeri, G 1995, 'Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion', Perfusion, vol. 10, no. 1, pp. 45-50. https://doi.org/10.1177/026765919501000108
Tao, Shu ; Calza, G. ; Lerzo, F. ; Virgone, A. ; Camassa, N. ; Panizzon, G. ; Bertolini, A. ; Brunelli, L. ; Moretti, R. ; Grasso, P. ; Ghiggeri, gm. / Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion. In: Perfusion. 1995 ; Vol. 10, No. 1. pp. 45-50.
@article{a072a7ca9f844531aa7da7d22b6cdadf,
title = "Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion",
abstract = "The glutathione (GSH) system is the main defence of tissues against free radicals and red blood cells (RBC) are the most efficient sites for GSH redox cycle activation. Total GSH was assayed during cardiopulmonary bypass (CPB) in RBC and serum from the coronary sinus, peripheral arteries and veins in 18 children corrected of their cardiac defect. Our conclusions are: (1) RBC-GSH redox cycle is activated during heart ischaemia and reperfusion; (2) the activation of intracellular GSH system is preponderant compared with the extracellular one; (3) variations in intraerythrocytic total GSH during heart ischaemia and perfusion are detectable in peripheral veins and arteries, which can be the convenient sites for monitoring changes in the GSH cycle; and (4) increased total GSH levels are present in RBC before aortic crossclamping: at the beginning of mechanical ventilation in veins and, when CPB is started, also in arteries.",
author = "Shu Tao and G. Calza and F. Lerzo and A. Virgone and N. Camassa and G. Panizzon and A. Bertolini and L. Brunelli and R. Moretti and P. Grasso and gm Ghiggeri",
year = "1995",
month = "1",
doi = "10.1177/026765919501000108",
language = "English (US)",
volume = "10",
pages = "45--50",
journal = "Perfusion (United Kingdom)",
issn = "0267-6591",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion

AU - Tao, Shu

AU - Calza, G.

AU - Lerzo, F.

AU - Virgone, A.

AU - Camassa, N.

AU - Panizzon, G.

AU - Bertolini, A.

AU - Brunelli, L.

AU - Moretti, R.

AU - Grasso, P.

AU - Ghiggeri, gm

PY - 1995/1

Y1 - 1995/1

N2 - The glutathione (GSH) system is the main defence of tissues against free radicals and red blood cells (RBC) are the most efficient sites for GSH redox cycle activation. Total GSH was assayed during cardiopulmonary bypass (CPB) in RBC and serum from the coronary sinus, peripheral arteries and veins in 18 children corrected of their cardiac defect. Our conclusions are: (1) RBC-GSH redox cycle is activated during heart ischaemia and reperfusion; (2) the activation of intracellular GSH system is preponderant compared with the extracellular one; (3) variations in intraerythrocytic total GSH during heart ischaemia and perfusion are detectable in peripheral veins and arteries, which can be the convenient sites for monitoring changes in the GSH cycle; and (4) increased total GSH levels are present in RBC before aortic crossclamping: at the beginning of mechanical ventilation in veins and, when CPB is started, also in arteries.

AB - The glutathione (GSH) system is the main defence of tissues against free radicals and red blood cells (RBC) are the most efficient sites for GSH redox cycle activation. Total GSH was assayed during cardiopulmonary bypass (CPB) in RBC and serum from the coronary sinus, peripheral arteries and veins in 18 children corrected of their cardiac defect. Our conclusions are: (1) RBC-GSH redox cycle is activated during heart ischaemia and reperfusion; (2) the activation of intracellular GSH system is preponderant compared with the extracellular one; (3) variations in intraerythrocytic total GSH during heart ischaemia and perfusion are detectable in peripheral veins and arteries, which can be the convenient sites for monitoring changes in the GSH cycle; and (4) increased total GSH levels are present in RBC before aortic crossclamping: at the beginning of mechanical ventilation in veins and, when CPB is started, also in arteries.

UR - http://www.scopus.com/inward/record.url?scp=0028954944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028954944&partnerID=8YFLogxK

U2 - 10.1177/026765919501000108

DO - 10.1177/026765919501000108

M3 - Article

C2 - 7795313

AN - SCOPUS:0028954944

VL - 10

SP - 45

EP - 50

JO - Perfusion (United Kingdom)

JF - Perfusion (United Kingdom)

SN - 0267-6591

IS - 1

ER -