ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

Robert V. Farese, Luisa F. Fanjul, C. M. de Ruiz Galarreta, John S Davis, Denise R. Cooper

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

Original languageEnglish (US)
Pages (from-to)2631-2637
Number of pages7
JournalLife Sciences
Volume41
Issue number24
DOIs
StatePublished - Dec 14 1987

Fingerprint

Diglycerides
Adrenocorticotropic Hormone
Protein Kinase C
Rats
Phosphotransferases
Phosphatidylinositols
Cytosol
Phospholipids
Chemical activation
Membranes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo. / Farese, Robert V.; Fanjul, Luisa F.; de Ruiz Galarreta, C. M.; Davis, John S; Cooper, Denise R.

In: Life Sciences, Vol. 41, No. 24, 14.12.1987, p. 2631-2637.

Research output: Contribution to journalArticle

Farese, Robert V. ; Fanjul, Luisa F. ; de Ruiz Galarreta, C. M. ; Davis, John S ; Cooper, Denise R. / ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo. In: Life Sciences. 1987 ; Vol. 41, No. 24. pp. 2631-2637.
@article{33e525f1ff004298a191b838b104ae69,
title = "ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo",
abstract = "Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.",
author = "Farese, {Robert V.} and Fanjul, {Luisa F.} and {de Ruiz Galarreta}, {C. M.} and Davis, {John S} and Cooper, {Denise R.}",
year = "1987",
month = "12",
day = "14",
doi = "10.1016/0024-3205(87)90277-3",
language = "English (US)",
volume = "41",
pages = "2631--2637",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "24",

}

TY - JOUR

T1 - ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

AU - Farese, Robert V.

AU - Fanjul, Luisa F.

AU - de Ruiz Galarreta, C. M.

AU - Davis, John S

AU - Cooper, Denise R.

PY - 1987/12/14

Y1 - 1987/12/14

N2 - Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

AB - Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

UR - http://www.scopus.com/inward/record.url?scp=0023623513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023623513&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(87)90277-3

DO - 10.1016/0024-3205(87)90277-3

M3 - Article

VL - 41

SP - 2631

EP - 2637

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 24

ER -