Acrolein mutagenicity in the v79 assay

R. A. Smith, Samuel Monroe Cohen, T. A. Lawson

Research output: Contribution to journalArticle

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Abstract

The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function.

Original languageEnglish (US)
Pages (from-to)497-498
Number of pages2
JournalCarcinogenesis
Volume11
Issue number3
DOIs
StatePublished - Mar 1 1990

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Acrolein
glycidol
Serum
Thioguanine
Poisons
Aldehydes
allyl alcohol

ASJC Scopus subject areas

  • Cancer Research

Cite this

Acrolein mutagenicity in the v79 assay. / Smith, R. A.; Cohen, Samuel Monroe; Lawson, T. A.

In: Carcinogenesis, Vol. 11, No. 3, 01.03.1990, p. 497-498.

Research output: Contribution to journalArticle

Smith, R. A. ; Cohen, Samuel Monroe ; Lawson, T. A. / Acrolein mutagenicity in the v79 assay. In: Carcinogenesis. 1990 ; Vol. 11, No. 3. pp. 497-498.
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