Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa

Ola Brønstad Brynildsrud, Vegard Eldholm, Jon Bohlin, Kennedy Uadiale, Stephen K Obaro, Dominique A. Caugant

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. After gradual introduction from 2010 of mass vaccination with a monovalent meningococcal A conjugate vaccine, serogroup A epidemics have been eliminated. Starting in 2013, the northwestern part of Nigeria has been affected by yearly outbreaks of meningitis caused by a novel strain of serogroup C Neisseria meningitidis (NmC). In 2015, the strain spread to the neighboring country Niger, where it caused a severe epidemic. Following a relative calm in 2016, the largest ever recorded epidemic of NmC broke out in Nigeria in 2017. Here, we describe the recent evolution of this new outbreak strain and show how the acquisition of capsule genes and virulence factors by a strain previously circulating asymptomatically in the African population led to the emergence of a virulent pathogen. This study illustrates the power of long-read whole-genome sequencing, combined with Illumina sequencing, for high-resolution epidemiological investigations.

Original languageEnglish (US)
Pages (from-to)5510-5515
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number21
DOIs
StatePublished - May 22 2018

Fingerprint

Western Africa
Virulence
Nigeria
Meningitis
Genes
Disease Outbreaks
Serogroup C Neisseria meningitidis
Meningococcal Meningitis
Mass Vaccination
Niger
Senegal
Conjugate Vaccines
Ethiopia
Africa South of the Sahara
Virulence Factors
Capsules
Genome
Population

Keywords

  • Horizontal gene transfer
  • Nanopore sequencing
  • Serogroup C meningococci
  • Virulence factors
  • Whole-genome sequencing

ASJC Scopus subject areas

  • General

Cite this

Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa. / Brynildsrud, Ola Brønstad; Eldholm, Vegard; Bohlin, Jon; Uadiale, Kennedy; Obaro, Stephen K; Caugant, Dominique A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 21, 22.05.2018, p. 5510-5515.

Research output: Contribution to journalArticle

Brynildsrud, Ola Brønstad ; Eldholm, Vegard ; Bohlin, Jon ; Uadiale, Kennedy ; Obaro, Stephen K ; Caugant, Dominique A. / Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 21. pp. 5510-5515.
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