Achievement and maintenance of sustained response during the treatment for adolescents with depression study continuation and maintenance therapy

Paul Rohde, Susan G. Silva, Simon T. Tonev, Betsy D. Kennard, Benedetto Vitiello, Christopher J Kratochvil, Mark A. Reinecke, John F. Curry, Anne D. Simons, John S. March

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Context: The Treatment for Adolescents With Depression Study evaluated fluoxetine (FLX), cognitive behavioral therapy (CBT), and FLX/CBT combination (COMB) vs pill placebo in 439 adolescents with major depressive disorder. Treatment consisted of 3 stages: (1) acute (12 weeks), (2) continuation (6 weeks), and (3) maintenance (18 weeks). Objective: To examine rates of achieving and maintaining sustained response during continuation and maintenance treatments. Design: Randomized controlled trial. Response was determined by blinded independent evaluators. Setting: Thirteen US sites. Patients: Two hundred forty-two FLX, CBT, and COMB patients in their assigned treatment at the end of stage 1. Interventions: Stage 2 treatment varied based on stage 1 response. Stage 3 consisted of 3 CBT and/or pharmacotherapy sessions and, if applicable, continued medication. Main Outcome Measures: Sustained response was defined as 2 consecutive Clinical Global Impression-Improvement ratings of 1 or 2 ("full response"). Patients achieving sustained response were classified on subsequent nonresponse status. Results: Among 95 patients (39.3%) who had not achieved sustained response by week 12 (29.1% COMB, 32.5% FLX, and 57.9% CBT), sustained response rates during stages 2 and 3 were 80.0% COMB, 61.5% FLX, and 77.3% CBT (difference not significant). Among the remaining 147 patients (60.7%) who achieved sustained response by week 12, CBT patients were more likely than FLX patients to maintain sustained response through week 36 (96.9% vs 74.1%; P=.007; 88.5% of COMB patients maintained sustained response through week 36). Total rates of sustained response by week 36 were 88.4% COMB, 82.5% FLX, and 75.0% CBT. Conclusions: Most adolescents with depression who had not achieved sustained response during acute treatment did achieve that level of improvement during continuation and maintenance therapies. The possibility that CBT may help the subset of adolescents with depression who achieve early sustained response maintain their response warrants further investigation. Trial Registration: clinicaltrials.gov Identifier: NCT00006286.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalArchives of general psychiatry
Volume65
Issue number4
DOIs
StatePublished - Jan 1 2008

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Cognitive Therapy
Fluoxetine
Maintenance
Depression
Therapeutics
Major Depressive Disorder
Randomized Controlled Trials
Placebos
Outcome Assessment (Health Care)
Drug Therapy

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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Achievement and maintenance of sustained response during the treatment for adolescents with depression study continuation and maintenance therapy. / Rohde, Paul; Silva, Susan G.; Tonev, Simon T.; Kennard, Betsy D.; Vitiello, Benedetto; Kratochvil, Christopher J; Reinecke, Mark A.; Curry, John F.; Simons, Anne D.; March, John S.

In: Archives of general psychiatry, Vol. 65, No. 4, 01.01.2008, p. 447-455.

Research output: Contribution to journalArticle

Rohde, Paul ; Silva, Susan G. ; Tonev, Simon T. ; Kennard, Betsy D. ; Vitiello, Benedetto ; Kratochvil, Christopher J ; Reinecke, Mark A. ; Curry, John F. ; Simons, Anne D. ; March, John S. / Achievement and maintenance of sustained response during the treatment for adolescents with depression study continuation and maintenance therapy. In: Archives of general psychiatry. 2008 ; Vol. 65, No. 4. pp. 447-455.
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abstract = "Context: The Treatment for Adolescents With Depression Study evaluated fluoxetine (FLX), cognitive behavioral therapy (CBT), and FLX/CBT combination (COMB) vs pill placebo in 439 adolescents with major depressive disorder. Treatment consisted of 3 stages: (1) acute (12 weeks), (2) continuation (6 weeks), and (3) maintenance (18 weeks). Objective: To examine rates of achieving and maintaining sustained response during continuation and maintenance treatments. Design: Randomized controlled trial. Response was determined by blinded independent evaluators. Setting: Thirteen US sites. Patients: Two hundred forty-two FLX, CBT, and COMB patients in their assigned treatment at the end of stage 1. Interventions: Stage 2 treatment varied based on stage 1 response. Stage 3 consisted of 3 CBT and/or pharmacotherapy sessions and, if applicable, continued medication. Main Outcome Measures: Sustained response was defined as 2 consecutive Clinical Global Impression-Improvement ratings of 1 or 2 ({"}full response{"}). Patients achieving sustained response were classified on subsequent nonresponse status. Results: Among 95 patients (39.3{\%}) who had not achieved sustained response by week 12 (29.1{\%} COMB, 32.5{\%} FLX, and 57.9{\%} CBT), sustained response rates during stages 2 and 3 were 80.0{\%} COMB, 61.5{\%} FLX, and 77.3{\%} CBT (difference not significant). Among the remaining 147 patients (60.7{\%}) who achieved sustained response by week 12, CBT patients were more likely than FLX patients to maintain sustained response through week 36 (96.9{\%} vs 74.1{\%}; P=.007; 88.5{\%} of COMB patients maintained sustained response through week 36). Total rates of sustained response by week 36 were 88.4{\%} COMB, 82.5{\%} FLX, and 75.0{\%} CBT. Conclusions: Most adolescents with depression who had not achieved sustained response during acute treatment did achieve that level of improvement during continuation and maintenance therapies. The possibility that CBT may help the subset of adolescents with depression who achieve early sustained response maintain their response warrants further investigation. Trial Registration: clinicaltrials.gov Identifier: NCT00006286.",
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N2 - Context: The Treatment for Adolescents With Depression Study evaluated fluoxetine (FLX), cognitive behavioral therapy (CBT), and FLX/CBT combination (COMB) vs pill placebo in 439 adolescents with major depressive disorder. Treatment consisted of 3 stages: (1) acute (12 weeks), (2) continuation (6 weeks), and (3) maintenance (18 weeks). Objective: To examine rates of achieving and maintaining sustained response during continuation and maintenance treatments. Design: Randomized controlled trial. Response was determined by blinded independent evaluators. Setting: Thirteen US sites. Patients: Two hundred forty-two FLX, CBT, and COMB patients in their assigned treatment at the end of stage 1. Interventions: Stage 2 treatment varied based on stage 1 response. Stage 3 consisted of 3 CBT and/or pharmacotherapy sessions and, if applicable, continued medication. Main Outcome Measures: Sustained response was defined as 2 consecutive Clinical Global Impression-Improvement ratings of 1 or 2 ("full response"). Patients achieving sustained response were classified on subsequent nonresponse status. Results: Among 95 patients (39.3%) who had not achieved sustained response by week 12 (29.1% COMB, 32.5% FLX, and 57.9% CBT), sustained response rates during stages 2 and 3 were 80.0% COMB, 61.5% FLX, and 77.3% CBT (difference not significant). Among the remaining 147 patients (60.7%) who achieved sustained response by week 12, CBT patients were more likely than FLX patients to maintain sustained response through week 36 (96.9% vs 74.1%; P=.007; 88.5% of COMB patients maintained sustained response through week 36). Total rates of sustained response by week 36 were 88.4% COMB, 82.5% FLX, and 75.0% CBT. Conclusions: Most adolescents with depression who had not achieved sustained response during acute treatment did achieve that level of improvement during continuation and maintenance therapies. The possibility that CBT may help the subset of adolescents with depression who achieve early sustained response maintain their response warrants further investigation. Trial Registration: clinicaltrials.gov Identifier: NCT00006286.

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