Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle

Shaunagh McDermott, Sarah P Thayer, Carlos Fernandez Del Castillo, Mari Mino-Kenudson, Ralph Weissleder, Mukesh G. Harisinghani

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4%at a nodal level and 83.3%and 80%at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)670-675
Number of pages6
JournalTranslational Oncology
Volume6
Issue number6
DOIs
StatePublished - Jan 1 2013

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Nanoparticles
Adenocarcinoma
Magnetic Resonance Imaging
Ferrosoferric Oxide
Lymph Nodes
Sensitivity and Specificity
Lymph Node Excision
Pancreatic Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. / McDermott, Shaunagh; Thayer, Sarah P; Castillo, Carlos Fernandez Del; Mino-Kenudson, Mari; Weissleder, Ralph; Harisinghani, Mukesh G.

In: Translational Oncology, Vol. 6, No. 6, 01.01.2013, p. 670-675.

Research output: Contribution to journalArticle

McDermott, Shaunagh ; Thayer, Sarah P ; Castillo, Carlos Fernandez Del ; Mino-Kenudson, Mari ; Weissleder, Ralph ; Harisinghani, Mukesh G. / Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. In: Translational Oncology. 2013 ; Vol. 6, No. 6. pp. 670-675.
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abstract = "Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5{\%} and 98.4{\%}at a nodal level and 83.3{\%}and 80{\%}at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.",
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AU - Weissleder, Ralph

AU - Harisinghani, Mukesh G.

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N2 - Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4%at a nodal level and 83.3%and 80%at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.

AB - Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4%at a nodal level and 83.3%and 80%at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.

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