Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Shibin Ma, Vipul Shukla, Leilei Fang, Karen A Gould, Shantaram S Joshi, Runqing Lu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

Original languageEnglish (US)
Pages (from-to)26430-26440
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013

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Genome-Wide Association Study
B-Cell Chronic Lymphocytic Leukemia
New Zealand
Single Nucleotide Polymorphism
Cell Survival
Homeostasis
B-Lymphocytes
Genes
Cells
interferon regulatory factor-4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4. / Ma, Shibin; Shukla, Vipul; Fang, Leilei; Gould, Karen A; Joshi, Shantaram S; Lu, Runqing.

In: Journal of Biological Chemistry, Vol. 288, No. 37, 13.09.2013, p. 26430-26440.

Research output: Contribution to journalArticle

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