Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning

Elizabeth C. Finger, Abigail A. Marsh, Derek G. Mitchell, Marguerite E. Reid, Courtney Sims, Salima Budhani, David S. Kosson, Gang Chen, Kenneth E. Towbin, Ellen Leibenluft, Daniel S. Pine, James R. Blair

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

Context: Children and adults with psychopathic traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity of psychopathic traits and attention-deficit/hyperactivity disorder, to our knowledge, no research has attempted to distinguish neural correlates of childhood psychopathic traits and attention-deficit/hyperactivity disorder. Objective: To determine the neural regions that underlie the reversal learning impairments in children with psychopathic traits plus conduct or oppositional defiant disorder. Design: Case-control study. Setting: Government clinical research institute. Participants: Forty-two adolescents aged 10 to 17 years: 14 with psychopathic traits and oppositional defiant disorder or conduct disorder, 14 with attention-deficit/hyperactivity disorder only, and 14 healthy controls. Main Outcome Measure: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging during a probabilistic reversal task. Results: Children with psychopathic traits showed abnormal responses within the ventromedial prefrontal cortex (Brodmann area 10) during punished reversal errors compared with children with attention-deficit/hyperactivity disorder and healthy children (P<.05 corrected for multiple comparisons). Conclusions: To our knowledge, this study provides the first evidence of abnormal ventromedial prefrontal cortex responsiveness in children with psychopathic traits and demonstrates this dysfunction was not attributable to comorbid attention-deficit/hyperactivity disorder. These findings suggest that reversal learning impairments in patients with developmental psychopathic traits relate to abnormal processing of reinforcement information.

Original languageEnglish (US)
Pages (from-to)586-594
Number of pages9
JournalArchives of general psychiatry
Volume65
Issue number5
DOIs
StatePublished - May 1 2008

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Reversal Learning
Prefrontal Cortex
Attention Deficit Disorder with Hyperactivity
Attention Deficit and Disruptive Behavior Disorders
Conduct Disorder
Automatic Data Processing
Case-Control Studies
Comorbidity
Decision Making
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Attention Deficit Hyperactivity Disorder
Research

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning. / Finger, Elizabeth C.; Marsh, Abigail A.; Mitchell, Derek G.; Reid, Marguerite E.; Sims, Courtney; Budhani, Salima; Kosson, David S.; Chen, Gang; Towbin, Kenneth E.; Leibenluft, Ellen; Pine, Daniel S.; Blair, James R.

In: Archives of general psychiatry, Vol. 65, No. 5, 01.05.2008, p. 586-594.

Research output: Contribution to journalArticle

Finger, EC, Marsh, AA, Mitchell, DG, Reid, ME, Sims, C, Budhani, S, Kosson, DS, Chen, G, Towbin, KE, Leibenluft, E, Pine, DS & Blair, JR 2008, 'Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning', Archives of general psychiatry, vol. 65, no. 5, pp. 586-594. https://doi.org/10.1001/archpsyc.65.5.586
Finger, Elizabeth C. ; Marsh, Abigail A. ; Mitchell, Derek G. ; Reid, Marguerite E. ; Sims, Courtney ; Budhani, Salima ; Kosson, David S. ; Chen, Gang ; Towbin, Kenneth E. ; Leibenluft, Ellen ; Pine, Daniel S. ; Blair, James R. / Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning. In: Archives of general psychiatry. 2008 ; Vol. 65, No. 5. pp. 586-594.
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