Abnormal right atrial performance in repaired tetralogy of Fallot: A CMR feature tracking analysis

Shelby Kutty, Quanliang Shang, Navya Joseph, Johannes T. Kowallick, Andreas Schuster, Michael Steinmetz, David Alan Danford, Phillip Beerbaum, Samir Sarikouch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). Methods TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF). Results The cohort had 311 subjects: 171 TOF (94 male, age 18.2 ± 8 years) and 140 healthy controls (69 male, 16.4 ± 11 years). RAEDVi, RALS, RVEDVi, RVLS, RAEF, and RVEF in TOF were 60.8 ± 17.1 ml/m2, 13.6 ± 5.7%, 120.3 ± 30.3 ml/m2, 12.3 ± 4.2%, 32.5 ± 9.9% and 51.2 ± 8.4% and differed from respective indices in controls: 51.7 ± 15.7 ml/m2, 27 ± 10.1%, 74 ± 19.0 ml/m2, 18.5 ± 5.3%, 54 ± 8% and 62.5 ± 5.5% (p < 0.001). RAEDVi and RALS correlated with RVLS (p = 0.004, < 0.001, r = 0.2,0.3). RAEDVi was higher in older TOF, while RALS did not increase with age. RAEDVi but not RALS correlated with RV systolic pressure(r = 0.2, 0). Neither RAEDVi nor RALS was associated with tricuspid regurgitation grade or peak oxygen uptake (r = 0.1, 0). Positive correlation was observed for RVEDVi with RAEDVi (p = 0.035, r = 0.2) and a trend toward negative correlation with RALS (p = 0.09, r = 0.1). Conclusion RALS, RAEDVi and RAEF are abnormal in TOF. Reduced RALS indicates decreased RA reservoir function. Because they correlate with other functional RV indices, these abnormalities may represent RA diastolic burden from chronic RV dysfunction in TOF. The young cohort age might explain the absence of RALS correlation to tricuspid regurgitation and peak oxygen uptake.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalInternational Journal of Cardiology
Volume248
DOIs
StatePublished - Dec 1 2017

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Tetralogy of Fallot
Magnetic Resonance Spectroscopy
Tricuspid Valve Insufficiency
Right Atrial Function
Oxygen
Stress Echocardiography
Exercise
Blood Pressure

Keywords

  • Cardiovascular magnetic resonance
  • Congenital heart disease
  • Feature tracking
  • Tetralogy of Fallot

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Abnormal right atrial performance in repaired tetralogy of Fallot : A CMR feature tracking analysis. / Kutty, Shelby; Shang, Quanliang; Joseph, Navya; Kowallick, Johannes T.; Schuster, Andreas; Steinmetz, Michael; Danford, David Alan; Beerbaum, Phillip; Sarikouch, Samir.

In: International Journal of Cardiology, Vol. 248, 01.12.2017, p. 136-142.

Research output: Contribution to journalArticle

Kutty, Shelby ; Shang, Quanliang ; Joseph, Navya ; Kowallick, Johannes T. ; Schuster, Andreas ; Steinmetz, Michael ; Danford, David Alan ; Beerbaum, Phillip ; Sarikouch, Samir. / Abnormal right atrial performance in repaired tetralogy of Fallot : A CMR feature tracking analysis. In: International Journal of Cardiology. 2017 ; Vol. 248. pp. 136-142.
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title = "Abnormal right atrial performance in repaired tetralogy of Fallot: A CMR feature tracking analysis",
abstract = "Background We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). Methods TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF). Results The cohort had 311 subjects: 171 TOF (94 male, age 18.2 ± 8 years) and 140 healthy controls (69 male, 16.4 ± 11 years). RAEDVi, RALS, RVEDVi, RVLS, RAEF, and RVEF in TOF were 60.8 ± 17.1 ml/m2, 13.6 ± 5.7{\%}, 120.3 ± 30.3 ml/m2, 12.3 ± 4.2{\%}, 32.5 ± 9.9{\%} and 51.2 ± 8.4{\%} and differed from respective indices in controls: 51.7 ± 15.7 ml/m2, 27 ± 10.1{\%}, 74 ± 19.0 ml/m2, 18.5 ± 5.3{\%}, 54 ± 8{\%} and 62.5 ± 5.5{\%} (p < 0.001). RAEDVi and RALS correlated with RVLS (p = 0.004, < 0.001, r = 0.2,0.3). RAEDVi was higher in older TOF, while RALS did not increase with age. RAEDVi but not RALS correlated with RV systolic pressure(r = 0.2, 0). Neither RAEDVi nor RALS was associated with tricuspid regurgitation grade or peak oxygen uptake (r = 0.1, 0). Positive correlation was observed for RVEDVi with RAEDVi (p = 0.035, r = 0.2) and a trend toward negative correlation with RALS (p = 0.09, r = 0.1). Conclusion RALS, RAEDVi and RAEF are abnormal in TOF. Reduced RALS indicates decreased RA reservoir function. Because they correlate with other functional RV indices, these abnormalities may represent RA diastolic burden from chronic RV dysfunction in TOF. The young cohort age might explain the absence of RALS correlation to tricuspid regurgitation and peak oxygen uptake.",
keywords = "Cardiovascular magnetic resonance, Congenital heart disease, Feature tracking, Tetralogy of Fallot",
author = "Shelby Kutty and Quanliang Shang and Navya Joseph and Kowallick, {Johannes T.} and Andreas Schuster and Michael Steinmetz and Danford, {David Alan} and Phillip Beerbaum and Samir Sarikouch",
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T1 - Abnormal right atrial performance in repaired tetralogy of Fallot

T2 - A CMR feature tracking analysis

AU - Kutty, Shelby

AU - Shang, Quanliang

AU - Joseph, Navya

AU - Kowallick, Johannes T.

AU - Schuster, Andreas

AU - Steinmetz, Michael

AU - Danford, David Alan

AU - Beerbaum, Phillip

AU - Sarikouch, Samir

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). Methods TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF). Results The cohort had 311 subjects: 171 TOF (94 male, age 18.2 ± 8 years) and 140 healthy controls (69 male, 16.4 ± 11 years). RAEDVi, RALS, RVEDVi, RVLS, RAEF, and RVEF in TOF were 60.8 ± 17.1 ml/m2, 13.6 ± 5.7%, 120.3 ± 30.3 ml/m2, 12.3 ± 4.2%, 32.5 ± 9.9% and 51.2 ± 8.4% and differed from respective indices in controls: 51.7 ± 15.7 ml/m2, 27 ± 10.1%, 74 ± 19.0 ml/m2, 18.5 ± 5.3%, 54 ± 8% and 62.5 ± 5.5% (p < 0.001). RAEDVi and RALS correlated with RVLS (p = 0.004, < 0.001, r = 0.2,0.3). RAEDVi was higher in older TOF, while RALS did not increase with age. RAEDVi but not RALS correlated with RV systolic pressure(r = 0.2, 0). Neither RAEDVi nor RALS was associated with tricuspid regurgitation grade or peak oxygen uptake (r = 0.1, 0). Positive correlation was observed for RVEDVi with RAEDVi (p = 0.035, r = 0.2) and a trend toward negative correlation with RALS (p = 0.09, r = 0.1). Conclusion RALS, RAEDVi and RAEF are abnormal in TOF. Reduced RALS indicates decreased RA reservoir function. Because they correlate with other functional RV indices, these abnormalities may represent RA diastolic burden from chronic RV dysfunction in TOF. The young cohort age might explain the absence of RALS correlation to tricuspid regurgitation and peak oxygen uptake.

AB - Background We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). Methods TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF). Results The cohort had 311 subjects: 171 TOF (94 male, age 18.2 ± 8 years) and 140 healthy controls (69 male, 16.4 ± 11 years). RAEDVi, RALS, RVEDVi, RVLS, RAEF, and RVEF in TOF were 60.8 ± 17.1 ml/m2, 13.6 ± 5.7%, 120.3 ± 30.3 ml/m2, 12.3 ± 4.2%, 32.5 ± 9.9% and 51.2 ± 8.4% and differed from respective indices in controls: 51.7 ± 15.7 ml/m2, 27 ± 10.1%, 74 ± 19.0 ml/m2, 18.5 ± 5.3%, 54 ± 8% and 62.5 ± 5.5% (p < 0.001). RAEDVi and RALS correlated with RVLS (p = 0.004, < 0.001, r = 0.2,0.3). RAEDVi was higher in older TOF, while RALS did not increase with age. RAEDVi but not RALS correlated with RV systolic pressure(r = 0.2, 0). Neither RAEDVi nor RALS was associated with tricuspid regurgitation grade or peak oxygen uptake (r = 0.1, 0). Positive correlation was observed for RVEDVi with RAEDVi (p = 0.035, r = 0.2) and a trend toward negative correlation with RALS (p = 0.09, r = 0.1). Conclusion RALS, RAEDVi and RAEF are abnormal in TOF. Reduced RALS indicates decreased RA reservoir function. Because they correlate with other functional RV indices, these abnormalities may represent RA diastolic burden from chronic RV dysfunction in TOF. The young cohort age might explain the absence of RALS correlation to tricuspid regurgitation and peak oxygen uptake.

KW - Cardiovascular magnetic resonance

KW - Congenital heart disease

KW - Feature tracking

KW - Tetralogy of Fallot

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