Abnormal gamma and beta MEG activity during finger movements in early-onset psychosis

Tony W Wilson, Erin Slason, Ryan Asherin, Eugene Kronberg, Peter D. Teale, Martin L. Reite, Donald C. Rojas

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Patients with psychosis often exhibit abnormalities in basic motor control, but little is known about the neural basis of these deficits. This study examines the neuro-dynamics of movement using magnetoencephalography (MEG) in adolescents with early-onset psychosis and typically developing controls. MEG data were imaged using beamforming then evaluated for task and group effects before, during, and after movement onsets. Primary findings included weaker activation in patients during movement execution in cerebellar cortices. Such aberrations likely contribute to the decreased motor control exhibited by patients with psychosis, and may reflect GABAergic-based inhibitory deficits comparable to those seen in cellular and system-level studies.

Original languageEnglish (US)
Pages (from-to)596-613
Number of pages18
JournalDevelopmental Neuropsychology
Volume36
Issue number5
DOIs
StatePublished - Jul 1 2011

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Magnetoencephalography
Psychotic Disorders
Fingers
Cerebellar Cortex

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

Cite this

Abnormal gamma and beta MEG activity during finger movements in early-onset psychosis. / Wilson, Tony W; Slason, Erin; Asherin, Ryan; Kronberg, Eugene; Teale, Peter D.; Reite, Martin L.; Rojas, Donald C.

In: Developmental Neuropsychology, Vol. 36, No. 5, 01.07.2011, p. 596-613.

Research output: Contribution to journalArticle

Wilson, TW, Slason, E, Asherin, R, Kronberg, E, Teale, PD, Reite, ML & Rojas, DC 2011, 'Abnormal gamma and beta MEG activity during finger movements in early-onset psychosis', Developmental Neuropsychology, vol. 36, no. 5, pp. 596-613. https://doi.org/10.1080/87565641.2011.555573
Wilson, Tony W ; Slason, Erin ; Asherin, Ryan ; Kronberg, Eugene ; Teale, Peter D. ; Reite, Martin L. ; Rojas, Donald C. / Abnormal gamma and beta MEG activity during finger movements in early-onset psychosis. In: Developmental Neuropsychology. 2011 ; Vol. 36, No. 5. pp. 596-613.
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