Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder

Erin B. McClure, Christopher S. Monk, Eric E. Nelson, Jessica M. Parrish, Abby Adler, R. James R. Blair, Stephen Fromm, Dennis S. Charney, Ellen Leibenluft, Monique Ernst, Daniel S. Pine

Research output: Contribution to journalArticle

297 Citations (Scopus)

Abstract

Context: Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues. Objective: To determine whether attention modulates amygdala and cortical responses to facial-threat cues differentially in adolescents with generalized anxiety disorder and in healthy adolescents. Design: Case-control study. Setting: Government clinical research institute. Participants: Fifteen adolescents with generalized anxiety disorder and 20 controls. Main Outcome Measures: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging. During imaging, participants completed a face-emotion rating task that systematically manipulated attention. Results: While attending to their own subjective fear, patients, but not controls, showed greater activation to fearful faces than to happy faces in a distributed network including the amygdala, ventral prefrontal cortex, and anterior cingulate cortex (P<.05, small-volume corrected, for all). Right amygdala findings appeared particularly strong. Functional connectivity analyses demonstrated positive correlations among the amygdala, ventral prefrontal cortex, and anterior cingulate cortex. Conclusions: This is the first evidence in juveniles that generalized anxiety disorder-associated patterns of pathologic fear circuit activation are particularly evident during certain attention states. Specifically, fear circuit hyperactivation occurred in an attention state involving focus on subjectively experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping the function of the adolescent human fear circuit.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalArchives of general psychiatry
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2007

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Anxiety Disorders
Fear
Pediatrics
Amygdala
Cues
Gyrus Cinguli
Prefrontal Cortex
Emotions
Case-Control Studies
Anxiety
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Research

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. / McClure, Erin B.; Monk, Christopher S.; Nelson, Eric E.; Parrish, Jessica M.; Adler, Abby; Blair, R. James R.; Fromm, Stephen; Charney, Dennis S.; Leibenluft, Ellen; Ernst, Monique; Pine, Daniel S.

In: Archives of general psychiatry, Vol. 64, No. 1, 01.01.2007, p. 97-106.

Research output: Contribution to journalArticle

McClure, EB, Monk, CS, Nelson, EE, Parrish, JM, Adler, A, Blair, RJR, Fromm, S, Charney, DS, Leibenluft, E, Ernst, M & Pine, DS 2007, 'Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder', Archives of general psychiatry, vol. 64, no. 1, pp. 97-106. https://doi.org/10.1001/archpsyc.64.1.97
McClure, Erin B. ; Monk, Christopher S. ; Nelson, Eric E. ; Parrish, Jessica M. ; Adler, Abby ; Blair, R. James R. ; Fromm, Stephen ; Charney, Dennis S. ; Leibenluft, Ellen ; Ernst, Monique ; Pine, Daniel S. / Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. In: Archives of general psychiatry. 2007 ; Vol. 64, No. 1. pp. 97-106.
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