Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine

A Magnetoencephalography Study

Xinyao Guo, Jing Xiang, Yingying Wang, Hope O'Brien, Marielle Kabbouche, Paul Horn, Scott W. Powers, Andrew D. Hershey

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Migraine attacks have been shown to interfere with normal function in the brain such as motor or sensory function. However, to date, there has been no clinical neurophysiology study focusing on the motor function in children with migraine during headache attacks. To investigate the motor function in children with migraine, twenty-six children with acute migraine, meeting International Classification of Headache Disorders criteria and age- and gender-matched healthy children were studied using a 275-channel magnetoencephalography system. A finger-tapping paradigm was designed to elicit neuromagnetic activation in the motor cortex. Children with migraine showed significantly prolonged latency of movement-evoked magnetic fields (MEF) during finger movement compared with the controls. The correlation coefficient of MEF latency and age in children with migraine was significantly different from that in healthy controls. The spectral power of high gamma (65-150 Hz) oscillations during finger movement in the primary motor cortex is also significantly higher in children with migraine than in controls. The alteration of responding latency and aberrant high gamma oscillations suggest that the developmental trajectory of motor function in children with migraine is impaired during migraine attacks and/or developmentally delayed. This finding indicates that childhood migraine may affect the development of brain function and result in long-term problems.

Original languageEnglish (US)
Article numbere50095
JournalPloS one
Volume7
Issue number11
DOIs
StatePublished - Nov 27 2012

Fingerprint

Magnetoencephalography
migraine
Motor Cortex
Migraine Disorders
Chemical activation
Brain
Fingers
headache
Neurophysiology
Magnetic fields
Magnetic Fields
magnetic fields
oscillation
motor cortex
magnetoencephalography
brain
Headache Disorders
Trajectories
neurophysiology
childhood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine : A Magnetoencephalography Study. / Guo, Xinyao; Xiang, Jing; Wang, Yingying; O'Brien, Hope; Kabbouche, Marielle; Horn, Paul; Powers, Scott W.; Hershey, Andrew D.

In: PloS one, Vol. 7, No. 11, e50095, 27.11.2012.

Research output: Contribution to journalArticle

Guo, Xinyao ; Xiang, Jing ; Wang, Yingying ; O'Brien, Hope ; Kabbouche, Marielle ; Horn, Paul ; Powers, Scott W. ; Hershey, Andrew D. / Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine : A Magnetoencephalography Study. In: PloS one. 2012 ; Vol. 7, No. 11.
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