Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging

Tony W. Wilson, Brandon J. Lew, Rachel K. Spooner, Michael T. Rezich, Alex I. Wiesman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Magnetoencephalography (MEG) is a noninvasive, silent, and totally passive neurophysiological imaging method with excellent temporal resolution (~ 1 ms) and good spatial precision (~ 3–5 mm). While MEG studies of neuroHIV remain relatively rare, the number of studies per year has sharply increased recently and this trend will likely continue into the foreseeable future. The current in-depth review focuses on the studies that have been conducted to date, which include investigations of somatosensory and visual modalities, resting-state, as well as motor control and higher-level functions such as working memory and visual attention. The review begins with an introduction to the principles and methods of MEG, and then transitions to a review of each of the empirical studies that have been conducted to date, separated by sensory modality for the basic studies and cognitive domain for the higher-level investigations. As such, this review attempts to be exhaustive in its coverage of empirical MEG studies of neuroHIV. Across studies major themes emerge including aberrant neural oscillatory activity in HIV-infected adults, both in primary sensory regions of the brain and higher-order executive regions. Many studies have also connected the amplitude of neural oscillations to behavioral and/or neuropsychological function in the study population, making a vital connection to performance and improving the veracity of the findings. One conspicuous emerging area is the use of MEG to distinguish cognitively-impaired from unimpaired HIV-infected adults, with major success reported and future studies sure to come. The review concludes with a summary of findings and suggested focus areas for future studies.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsJames T. Becker, Ann D. Cohen
PublisherElsevier B.V.
Pages285-320
Number of pages36
ISBN (Print)9780128183618
DOIs
StatePublished - 2019

Publication series

NameProgress in Molecular Biology and Translational Science
Volume165
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Fingerprint

HIV
Magnetoencephalography
Brain
Short-Term Memory
Population

Keywords

  • Aging
  • Alpha
  • Attention
  • Beta
  • Connectivity
  • Gamma
  • HAND
  • HIV-infected
  • Motor
  • Oscillation
  • Theta
  • Visual

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Wilson, T. W., Lew, B. J., Spooner, R. K., Rezich, M. T., & Wiesman, A. I. (2019). Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging. In J. T. Becker, & A. D. Cohen (Eds.), Progress in Molecular Biology and Translational Science (pp. 285-320). (Progress in Molecular Biology and Translational Science; Vol. 165). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2019.04.008

Aberrant brain dynamics in neuroHIV : Evidence from magnetoencephalographic (MEG) imaging. / Wilson, Tony W.; Lew, Brandon J.; Spooner, Rachel K.; Rezich, Michael T.; Wiesman, Alex I.

Progress in Molecular Biology and Translational Science. ed. / James T. Becker; Ann D. Cohen. Elsevier B.V., 2019. p. 285-320 (Progress in Molecular Biology and Translational Science; Vol. 165).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wilson, TW, Lew, BJ, Spooner, RK, Rezich, MT & Wiesman, AI 2019, Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging. in JT Becker & AD Cohen (eds), Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science, vol. 165, Elsevier B.V., pp. 285-320. https://doi.org/10.1016/bs.pmbts.2019.04.008
Wilson TW, Lew BJ, Spooner RK, Rezich MT, Wiesman AI. Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging. In Becker JT, Cohen AD, editors, Progress in Molecular Biology and Translational Science. Elsevier B.V. 2019. p. 285-320. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/bs.pmbts.2019.04.008
Wilson, Tony W. ; Lew, Brandon J. ; Spooner, Rachel K. ; Rezich, Michael T. ; Wiesman, Alex I. / Aberrant brain dynamics in neuroHIV : Evidence from magnetoencephalographic (MEG) imaging. Progress in Molecular Biology and Translational Science. editor / James T. Becker ; Ann D. Cohen. Elsevier B.V., 2019. pp. 285-320 (Progress in Molecular Biology and Translational Science).
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