A Textile Dressing for Temporal and Dosage Controlled Drug Delivery

Pooria Mostafalu, Gita Kiaee, Giorgio Giatsidis, Akbar Khalilpour, Mahboobeh Nabavinia, Mehmet R. Dokmeci, Sameer Sonkusale, Dennis P. Orgill, Ali Tamayol, Ali Khademhosseini

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chronic wounds do not heal in an orderly fashion in part due to the lack of timely release of biological factors essential for healing. Topical administration of various therapeutic factors at different stages is shown to enhance the healing rate of chronic wounds. Developing a wound dressing that can deliver biomolecules with a predetermined spatial and temporal pattern would be beneficial for effective treatment of chronic wounds. Here, an actively controlled wound dressing is fabricated using composite fibers with a core electrical heater covered by a layer of hydrogel containing thermoresponsive drug carriers. The fibers are loaded with different drugs and biological factors and are then assembled using textile processes to create a flexible and wearable wound dressing. These fibers can be individually addressed to enable on-demand release of different drugs with a controlled temporal profile. Here, the effectiveness of the engineered dressing for on-demand release of antibiotics and vascular endothelial growth factor (VEGF) is demonstrated for eliminating bacterial infection and inducing angiogenesis in vitro. The effectiveness of the VEGF release on improving healing rate is also demonstrated in a murine model of diabetic wounds.

Original languageEnglish (US)
JournalAdvanced Functional Materials
DOIs
StateAccepted/In press - 2017

Fingerprint

Controlled drug delivery
textiles
delivery
Textiles
drugs
Biological Factors
healing
dosage
Vascular Endothelial Growth Factor A
Fibers
Drug Carriers
Hydrogel
Biomolecules
Antibiotics
Hydrogels
Pharmaceutical Preparations
angiogenesis
fibers
antibiotics
Anti-Bacterial Agents

Keywords

  • Biotextiles
  • Flexible wound dressings
  • Smart wound dressings
  • Stimuli-responsive drug delivery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Mostafalu, P., Kiaee, G., Giatsidis, G., Khalilpour, A., Nabavinia, M., Dokmeci, M. R., ... Khademhosseini, A. (Accepted/In press). A Textile Dressing for Temporal and Dosage Controlled Drug Delivery. Advanced Functional Materials. https://doi.org/10.1002/adfm.201702399

A Textile Dressing for Temporal and Dosage Controlled Drug Delivery. / Mostafalu, Pooria; Kiaee, Gita; Giatsidis, Giorgio; Khalilpour, Akbar; Nabavinia, Mahboobeh; Dokmeci, Mehmet R.; Sonkusale, Sameer; Orgill, Dennis P.; Tamayol, Ali; Khademhosseini, Ali.

In: Advanced Functional Materials, 2017.

Research output: Contribution to journalArticle

Mostafalu, P, Kiaee, G, Giatsidis, G, Khalilpour, A, Nabavinia, M, Dokmeci, MR, Sonkusale, S, Orgill, DP, Tamayol, A & Khademhosseini, A 2017, 'A Textile Dressing for Temporal and Dosage Controlled Drug Delivery', Advanced Functional Materials. https://doi.org/10.1002/adfm.201702399
Mostafalu P, Kiaee G, Giatsidis G, Khalilpour A, Nabavinia M, Dokmeci MR et al. A Textile Dressing for Temporal and Dosage Controlled Drug Delivery. Advanced Functional Materials. 2017. https://doi.org/10.1002/adfm.201702399
Mostafalu, Pooria ; Kiaee, Gita ; Giatsidis, Giorgio ; Khalilpour, Akbar ; Nabavinia, Mahboobeh ; Dokmeci, Mehmet R. ; Sonkusale, Sameer ; Orgill, Dennis P. ; Tamayol, Ali ; Khademhosseini, Ali. / A Textile Dressing for Temporal and Dosage Controlled Drug Delivery. In: Advanced Functional Materials. 2017.
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