A systematic review of the effect of thermal processing on the allergenicity of tree nuts

L. J. Masthoff, R. Hoff, K. C.M. Verhoeckx, H. Van Os-Medendorp, A. Michelsen-Huisman, J. L. Baumert, S. G. Pasmans, Y. Meijer, A. C. Knulst

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Background Allergenicity of foods can be influenced by processing. Tree nuts are an important source of nutrition and increasingly consumed; however, processing methods are quite variable and data are currently lacking on the effects of processing on allergenicity. Objective To perform a systematic literature review on the effects of food processing on the allergenicity of tree nuts. Methods A systematic literature search of PubMed and Embase databases was performed, with screening of references, related articles and citations. Studies were included if they assessed the allergenicity or immunogenicity of processed nuts. Results The search resulted in 32 articles suitable for analysis. Clinical studies indicate that roasting reduces the allergenicity of hazelnut in individuals with a birch pollen allergy and reactivity to raw hazelnut. Thermal processing may reduce the allergenicity of the PR-10 protein in hazelnut and almond in vitro. The majority of the in vitro studies investigating the allergenicity of nonspecific lipid transfer proteins (nsLTPs) and seed storage proteins in hazelnut, almond, cashew nut, Brazil nut, walnut, pecan nut and pistachio nut show heat stability towards different thermal processing methods. Conclusion Thermal processing may reduce allergenicity of PR-10 proteins in hazelnut and almond, in contrast to nsLTPs and seed storage proteins. This has important implications for source materials used for IgE testing and food challenges and diet advice.

Original languageEnglish (US)
Pages (from-to)983-993
Number of pages11
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Nuts
Corylus
Hot Temperature
Seed Storage Proteins
Bertholletia
Carya
Anacardium
Pistacia
Juglans
Food
Betula
Food Handling
Seasonal Allergic Rhinitis
PubMed
Immunoglobulin E
Proteins
Databases
Diet
Prunus dulcis

Keywords

  • IgE
  • allergens
  • food allergens
  • food allergy
  • in vitro tests

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Masthoff, L. J., Hoff, R., Verhoeckx, K. C. M., Van Os-Medendorp, H., Michelsen-Huisman, A., Baumert, J. L., ... Knulst, A. C. (2013). A systematic review of the effect of thermal processing on the allergenicity of tree nuts. Allergy: European Journal of Allergy and Clinical Immunology, 68(8), 983-993. https://doi.org/10.1111/all.12185

A systematic review of the effect of thermal processing on the allergenicity of tree nuts. / Masthoff, L. J.; Hoff, R.; Verhoeckx, K. C.M.; Van Os-Medendorp, H.; Michelsen-Huisman, A.; Baumert, J. L.; Pasmans, S. G.; Meijer, Y.; Knulst, A. C.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 68, No. 8, 01.08.2013, p. 983-993.

Research output: Contribution to journalReview article

Masthoff, LJ, Hoff, R, Verhoeckx, KCM, Van Os-Medendorp, H, Michelsen-Huisman, A, Baumert, JL, Pasmans, SG, Meijer, Y & Knulst, AC 2013, 'A systematic review of the effect of thermal processing on the allergenicity of tree nuts', Allergy: European Journal of Allergy and Clinical Immunology, vol. 68, no. 8, pp. 983-993. https://doi.org/10.1111/all.12185
Masthoff, L. J. ; Hoff, R. ; Verhoeckx, K. C.M. ; Van Os-Medendorp, H. ; Michelsen-Huisman, A. ; Baumert, J. L. ; Pasmans, S. G. ; Meijer, Y. ; Knulst, A. C. / A systematic review of the effect of thermal processing on the allergenicity of tree nuts. In: Allergy: European Journal of Allergy and Clinical Immunology. 2013 ; Vol. 68, No. 8. pp. 983-993.
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