A Systematic Review of Genetic Influence on Psychological Resilience

Kosuke Niitsu, Michael J. Rice, Julia F. Houfek, Scott F Stoltenberg, Kevin A Kupzyk, Cecilia R. Barron

Research output: Contribution to journalArticle

Abstract

When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well, described as resilience. Resilience is a complex biopsychosocial phenomenon conceptualized as adaptation to adversity influenced by an individual’s genetic variants, epistasis, epigenetics, and gene-by-environment interactions. Studies on psychological resilience have focused on behavioral and psychosocial variables with far less examination of the genetic contributions. The purpose of this review is to identify specific genetic variants contributing to the biological capacity for psychological resilience. PubMed and PsycINFO were searched using the following key words: psychological resilience AND genotype(s). Additional articles were identified from the Human Genome Epidemiology Navigator using the term resilience, psychological. Ten studies met the criteria. Six genes were empirically associated with psychological resilience: serotonin-transporter-linked polymorphic region (5-HTTLPR), dopamine receptor D4, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone receptor 1, oxytocin receptor and regulator of G-protein signaling 2. The findings of this systematic review suggest that the L/L or L’/L’ genotype of 5-HTTLPR and rs25531 in children/adolescents and the S/S or S’/S’ genotype in adults are most frequently related to resilience. Additionally, the Val/Val genotype of rs6265 in BDNF in Caucasians was also associated with resilience. There are numerous factors contributing to the complexity of determining the genetic influence on resilience including analysis of rs25531, assumptions of the mode of inheritance, operationalization of resilience, demographic and population characteristics, sample size, and other types of genetic influence including epistasis and epigenetics. While current evidence is supportive, further investigation of the genetic influence on resilience is required.

LanguageEnglish (US)
Pages61-71
Number of pages11
JournalBiological Research for Nursing
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Psychological Resilience
Genotype
Brain-Derived Neurotrophic Factor
Epigenomics
Genetic Epistasis
GTP-Binding Protein Regulators
Dopamine D4 Receptors
Oxytocin Receptors
Corticotropin-Releasing Hormone Receptors
Gene-Environment Interaction
Serotonin Plasma Membrane Transport Proteins
Human Genome
Population Characteristics
Post-Traumatic Stress Disorders
PubMed
Sample Size
Epidemiology
Demography
Genes

Keywords

  • adversity
  • gene-by-environment interaction
  • genetics
  • genotype
  • psychological resilience
  • systematic review

ASJC Scopus subject areas

  • Research and Theory

Cite this

A Systematic Review of Genetic Influence on Psychological Resilience. / Niitsu, Kosuke; Rice, Michael J.; Houfek, Julia F.; Stoltenberg, Scott F; Kupzyk, Kevin A; Barron, Cecilia R.

In: Biological Research for Nursing, Vol. 21, No. 1, 01.01.2019, p. 61-71.

Research output: Contribution to journalArticle

Niitsu, Kosuke ; Rice, Michael J. ; Houfek, Julia F. ; Stoltenberg, Scott F ; Kupzyk, Kevin A ; Barron, Cecilia R. / A Systematic Review of Genetic Influence on Psychological Resilience. In: Biological Research for Nursing. 2019 ; Vol. 21, No. 1. pp. 61-71.
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