A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders

Vanja Rozenblat, Deborah Ong, Matthew Fuller-Tyszkiewicz, Kirsti Akkermann, David Collier, Rutger C.M.E. Engels, Fernando Fernandez-Aranda, Jaanus Harro, Judith R. Homberg, Andreas Karwautz, Evelyn Kiive, Kelly L. Klump, Christine L. Larson, Sarah E. Racine, Jodie Richardson, Howard Steiger, Scott F. Stoltenberg, Tatjana van Strien, Gudrun Wagner, Janet TreasureIsabel Krug

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.

Original languageEnglish (US)
Pages (from-to)62-72
Number of pages11
JournalJournal of Psychiatric Research
Volume84
DOIs
StatePublished - Jan 1 2017

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Sex Offenses
Psychology
Sample Size
Gene-Environment Interaction
Genetic Research
PubMed
Genetic Promoter Regions
Genes
Meta-Analysis
Eating
Alleles
Depression
Feeding and Eating Disorders
Systematic Review
Psychological
Eating Disorders
Polymorphism
Interaction
Research

Keywords

  • 5-HTTLPR
  • Bulimia nervosa
  • Eating disorders
  • Gene-environment interaction
  • Meta-analysis
  • Systematic review

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders. / Rozenblat, Vanja; Ong, Deborah; Fuller-Tyszkiewicz, Matthew; Akkermann, Kirsti; Collier, David; Engels, Rutger C.M.E.; Fernandez-Aranda, Fernando; Harro, Jaanus; Homberg, Judith R.; Karwautz, Andreas; Kiive, Evelyn; Klump, Kelly L.; Larson, Christine L.; Racine, Sarah E.; Richardson, Jodie; Steiger, Howard; Stoltenberg, Scott F.; van Strien, Tatjana; Wagner, Gudrun; Treasure, Janet; Krug, Isabel.

In: Journal of Psychiatric Research, Vol. 84, 01.01.2017, p. 62-72.

Research output: Contribution to journalReview article

Rozenblat, V, Ong, D, Fuller-Tyszkiewicz, M, Akkermann, K, Collier, D, Engels, RCME, Fernandez-Aranda, F, Harro, J, Homberg, JR, Karwautz, A, Kiive, E, Klump, KL, Larson, CL, Racine, SE, Richardson, J, Steiger, H, Stoltenberg, SF, van Strien, T, Wagner, G, Treasure, J & Krug, I 2017, 'A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders', Journal of Psychiatric Research, vol. 84, pp. 62-72. https://doi.org/10.1016/j.jpsychires.2016.09.023
Rozenblat, Vanja ; Ong, Deborah ; Fuller-Tyszkiewicz, Matthew ; Akkermann, Kirsti ; Collier, David ; Engels, Rutger C.M.E. ; Fernandez-Aranda, Fernando ; Harro, Jaanus ; Homberg, Judith R. ; Karwautz, Andreas ; Kiive, Evelyn ; Klump, Kelly L. ; Larson, Christine L. ; Racine, Sarah E. ; Richardson, Jodie ; Steiger, Howard ; Stoltenberg, Scott F. ; van Strien, Tatjana ; Wagner, Gudrun ; Treasure, Janet ; Krug, Isabel. / A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders. In: Journal of Psychiatric Research. 2017 ; Vol. 84. pp. 62-72.
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abstract = "Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5{\%} female) and two clinical (n = 426, 100{\%} female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.",
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T1 - A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders

AU - Rozenblat, Vanja

AU - Ong, Deborah

AU - Fuller-Tyszkiewicz, Matthew

AU - Akkermann, Kirsti

AU - Collier, David

AU - Engels, Rutger C.M.E.

AU - Fernandez-Aranda, Fernando

AU - Harro, Jaanus

AU - Homberg, Judith R.

AU - Karwautz, Andreas

AU - Kiive, Evelyn

AU - Klump, Kelly L.

AU - Larson, Christine L.

AU - Racine, Sarah E.

AU - Richardson, Jodie

AU - Steiger, Howard

AU - Stoltenberg, Scott F.

AU - van Strien, Tatjana

AU - Wagner, Gudrun

AU - Treasure, Janet

AU - Krug, Isabel

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.

AB - Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.

KW - 5-HTTLPR

KW - Bulimia nervosa

KW - Eating disorders

KW - Gene-environment interaction

KW - Meta-analysis

KW - Systematic review

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