A survey of cytosine and cytidine salvage in fungi

Rajiv K. Kulkarni, Joseph A. Krzycki, Kenneth W. Nickerson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Twenty-five fungi, including representatives from each of the four major classes, were surveyed with regard to their ability to utilize exogenous cytosine and cytidine. Two assay methods were employed: incorporation of radiolabeled precursors and sensitivity to 5-fluorinated structural analogs. The following taxonomic correlations were found: (i) the Ascomycetes utilize exogenous cytidine and/or cytosine; (ii) the lower fungi utilize cytidine but not cytosine; (iii) the Basidiomycetes utilize neither; and (iv) the Dueteromycetes, with some exceptions, closely resemble the Ascomycetes. Additionally, natural resistance to 5-fluorocytosine via both defective transport and pyrimidine excretion was observed.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalExperimental Mycology
Volume4
Issue number2
DOIs
StatePublished - Jun 1980

Fingerprint

Cytidine
Cytosine
Ascomycota
Fungi
Flucytosine
Basidiomycota
Innate Immunity
Surveys and Questionnaires

Keywords

  • 5-fluorocytosine
  • cytosine salvage
  • fungal taxonomy
  • pyrimidine excretion

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

Cite this

A survey of cytosine and cytidine salvage in fungi. / Kulkarni, Rajiv K.; Krzycki, Joseph A.; Nickerson, Kenneth W.

In: Experimental Mycology, Vol. 4, No. 2, 06.1980, p. 116-122.

Research output: Contribution to journalArticle

Kulkarni, Rajiv K. ; Krzycki, Joseph A. ; Nickerson, Kenneth W. / A survey of cytosine and cytidine salvage in fungi. In: Experimental Mycology. 1980 ; Vol. 4, No. 2. pp. 116-122.
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