A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study

Elbert D. Glover, Scott J. Leischow, Stephen I. Rennard, Penny N. Glover, David Daughton, John N. Quiring, F. Howard Schneider, Peter J. Mione

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate a sublingual formulation of lobeline sulfate for smoking cessation. Methods: Random assignment of 180 healthy smokers to treatment (n=90) or placebo (n=90). Treatment was self-administering a 7.5 mg lobeline sulfate sublingual or placebo tablet 9 times per day for 6 weeks. Results: No difference in cessation efficacy between placebo and active treatment. Among highly dependent smokers who completed the trial, there was a trend for higher cessation rates in the active group. Conclusion: This pilot study failed to demonstrate smoking-cessation efficacy. However, data suggest continued studies to evaluate lobeline sulfate for smoking cessation.

Original languageEnglish (US)
Pages (from-to)62-74
Number of pages13
JournalAmerican Journal of Health Behavior
Volume22
Issue number1
StatePublished - Jan 1 1998

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Lobeline
Smoking Cessation
smoking
Placebos
Tablets
Therapeutics
trend
Group

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

Cite this

Glover, E. D., Leischow, S. J., Rennard, S. I., Glover, P. N., Daughton, D., Quiring, J. N., ... Mione, P. J. (1998). A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study. American Journal of Health Behavior, 22(1), 62-74.

A Smoking Cessation Trial with Lobeline Sulfate : A Pilot Study. / Glover, Elbert D.; Leischow, Scott J.; Rennard, Stephen I.; Glover, Penny N.; Daughton, David; Quiring, John N.; Howard Schneider, F.; Mione, Peter J.

In: American Journal of Health Behavior, Vol. 22, No. 1, 01.01.1998, p. 62-74.

Research output: Contribution to journalArticle

Glover, ED, Leischow, SJ, Rennard, SI, Glover, PN, Daughton, D, Quiring, JN, Howard Schneider, F & Mione, PJ 1998, 'A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study', American Journal of Health Behavior, vol. 22, no. 1, pp. 62-74.
Glover ED, Leischow SJ, Rennard SI, Glover PN, Daughton D, Quiring JN et al. A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study. American Journal of Health Behavior. 1998 Jan 1;22(1):62-74.
Glover, Elbert D. ; Leischow, Scott J. ; Rennard, Stephen I. ; Glover, Penny N. ; Daughton, David ; Quiring, John N. ; Howard Schneider, F. ; Mione, Peter J. / A Smoking Cessation Trial with Lobeline Sulfate : A Pilot Study. In: American Journal of Health Behavior. 1998 ; Vol. 22, No. 1. pp. 62-74.
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