Abstract
The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-123 |
| Number of pages | 7 |
| Journal | Journal of Neuro-Oncology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 1993 |
Fingerprint
Keywords
- bromodeoxyuridine
- histological types
- malignant
- meningioma
- primary cultures
- recurrent
- sequential labeling index
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research
Cite this
A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine. / Kharbanda, Kusum; Karak, Asis K.; Sarkar, Chitra; Dinda, Amit K.; Mathur, Meera; Roy, S.
In: Journal of Neuro-Oncology, Vol. 16, No. 2, 01.06.1993, p. 117-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine
AU - Kharbanda, Kusum
AU - Karak, Asis K.
AU - Sarkar, Chitra
AU - Dinda, Amit K.
AU - Mathur, Meera
AU - Roy, S.
PY - 1993/6/1
Y1 - 1993/6/1
N2 - The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.
AB - The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.
KW - bromodeoxyuridine
KW - histological types
KW - malignant
KW - meningioma
KW - primary cultures
KW - recurrent
KW - sequential labeling index
UR - http://www.scopus.com/inward/record.url?scp=0027517395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027517395&partnerID=8YFLogxK
U2 - 10.1007/BF01324698
DO - 10.1007/BF01324698
M3 - Article
C2 - 8289089
AN - SCOPUS:0027517395
VL - 16
SP - 117
EP - 123
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 2
ER -