A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

Kusum Kharbanda, Asis K. Karak, Chitra Sarkar, Amit K. Dinda, Meera Mathur, S. Roy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalJournal of Neuro-Oncology
Volume16
Issue number2
DOIs
StatePublished - Jun 1 1993

Fingerprint

Meningioma
Bromodeoxyuridine
Growth
In Vitro Techniques

Keywords

  • bromodeoxyuridine
  • histological types
  • malignant
  • meningioma
  • primary cultures
  • recurrent
  • sequential labeling index

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine. / Kharbanda, Kusum; Karak, Asis K.; Sarkar, Chitra; Dinda, Amit K.; Mathur, Meera; Roy, S.

In: Journal of Neuro-Oncology, Vol. 16, No. 2, 01.06.1993, p. 117-123.

Research output: Contribution to journalArticle

Kharbanda, Kusum ; Karak, Asis K. ; Sarkar, Chitra ; Dinda, Amit K. ; Mathur, Meera ; Roy, S. / A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine. In: Journal of Neuro-Oncology. 1993 ; Vol. 16, No. 2. pp. 117-123.
@article{e2dfd26c26c1460ebdde88b208c41545,
title = "A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine",
abstract = "The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.",
keywords = "bromodeoxyuridine, histological types, malignant, meningioma, primary cultures, recurrent, sequential labeling index",
author = "Kusum Kharbanda and Karak, {Asis K.} and Chitra Sarkar and Dinda, {Amit K.} and Meera Mathur and S. Roy",
year = "1993",
month = "6",
day = "1",
doi = "10.1007/BF01324698",
language = "English (US)",
volume = "16",
pages = "117--123",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

AU - Kharbanda, Kusum

AU - Karak, Asis K.

AU - Sarkar, Chitra

AU - Dinda, Amit K.

AU - Mathur, Meera

AU - Roy, S.

PY - 1993/6/1

Y1 - 1993/6/1

N2 - The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

AB - The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

KW - bromodeoxyuridine

KW - histological types

KW - malignant

KW - meningioma

KW - primary cultures

KW - recurrent

KW - sequential labeling index

UR - http://www.scopus.com/inward/record.url?scp=0027517395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027517395&partnerID=8YFLogxK

U2 - 10.1007/BF01324698

DO - 10.1007/BF01324698

M3 - Article

C2 - 8289089

AN - SCOPUS:0027517395

VL - 16

SP - 117

EP - 123

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

IS - 2

ER -