A role for the NLRP3 inflammasome in metabolic diseases - Did Warburg miss inflammation?

Haitao Wen, Jenny P.Y. Ting, Luke A.J. O'Neill

Research output: Contribution to journalReview article

272 Citations (Scopus)

Abstract

The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalNature Immunology
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2012

Fingerprint

Inflammasomes
Metabolic Diseases
Inflammation
Caspase 1
Interleukin-18
Gout
Glycolysis
Interleukin-1
Type 2 Diabetes Mellitus
Atherosclerosis
Obesity
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

A role for the NLRP3 inflammasome in metabolic diseases - Did Warburg miss inflammation? / Wen, Haitao; Ting, Jenny P.Y.; O'Neill, Luke A.J.

In: Nature Immunology, Vol. 13, No. 4, 01.04.2012, p. 352-357.

Research output: Contribution to journalReview article

Wen, Haitao ; Ting, Jenny P.Y. ; O'Neill, Luke A.J. / A role for the NLRP3 inflammasome in metabolic diseases - Did Warburg miss inflammation?. In: Nature Immunology. 2012 ; Vol. 13, No. 4. pp. 352-357.
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