A role for cadherins in cellular signaling and differentiation

Karen A. Knudsen, Christy Frankowski, Keith R. Johnson, Margaret J. Wheelock

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Cadherins form a family of cell-cell adhesion proteins that are critical to normal embryonic development. Expression of the various family members is regulated in a complex pattern during embryogenesis. Both reduced and inappropriate expression of cadherins have been associated with abnormal tissue formation in embryos and tumorigenesis in mature organisms. Evidence is accumulating that signals unique to individual members of the cadherin family, as well as signals common to multiple cadherins, contribute to the differentiated phenotype of various cell types. While a complete understanding of the regulation of cadherin expression of the molecular nature of intracellular signaling downstream of cadherin adhesion is essential to an understanding of embryogenesis and tumorigenesis, our knowledge in both areas is inadequate. Clearly, elucidating the factors and conditions that regulate cadherin expression and defining the signaling pathways activated by cadherins are frontiers for future research.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalJournal of Cellular Biochemistry
Issue numberSUPPL. 30/31
StatePublished - Dec 1 1998

Fingerprint

Cell signaling
Cadherins
Embryonic Development
Carcinogenesis
Cell adhesion
Cell Adhesion
Adhesion
Embryonic Structures
Tissue
Phenotype

Keywords

  • Cadherin
  • Catenin
  • Differentiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Knudsen, K. A., Frankowski, C., Johnson, K. R., & Wheelock, M. J. (1998). A role for cadherins in cellular signaling and differentiation. Journal of Cellular Biochemistry, (SUPPL. 30/31), 168-176.

A role for cadherins in cellular signaling and differentiation. / Knudsen, Karen A.; Frankowski, Christy; Johnson, Keith R.; Wheelock, Margaret J.

In: Journal of Cellular Biochemistry, No. SUPPL. 30/31, 01.12.1998, p. 168-176.

Research output: Contribution to journalArticle

Knudsen, KA, Frankowski, C, Johnson, KR & Wheelock, MJ 1998, 'A role for cadherins in cellular signaling and differentiation', Journal of Cellular Biochemistry, no. SUPPL. 30/31, pp. 168-176.
Knudsen KA, Frankowski C, Johnson KR, Wheelock MJ. A role for cadherins in cellular signaling and differentiation. Journal of Cellular Biochemistry. 1998 Dec 1;(SUPPL. 30/31):168-176.
Knudsen, Karen A. ; Frankowski, Christy ; Johnson, Keith R. ; Wheelock, Margaret J. / A role for cadherins in cellular signaling and differentiation. In: Journal of Cellular Biochemistry. 1998 ; No. SUPPL. 30/31. pp. 168-176.
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