A retrospective study on the effects of steroid administration and prolongation of the latent phase in patients with preterm premature rupture of the membranes

Fernando Arias, Alfred B. Knight, Paul G Tomich

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To address the issues of whether corticosteroid treatment and prolongation of the latent phase improve the outcome of pregnancy in patients with preterm premature rupture of the membranes, we studied 96 patients with premature rupture of the membranes who were delivered of infants of adequate weight for gestational age with birth weights between 751 and 2000 gm and who had a latent period longer than 48 hours. Of these 96 infants, 53 received treatment with steroids and tocolytic agents and 43 received no treatment. We found a significant decrease in perinatal mortality and in the incidence of moderate and severe hyaline membrane disease in infants whose mothers received glucocorticoids. The protective effect of glucocorticoid therapy was limited to infants with a birth weight between 751 and 1000 gm or with a gestational age of 27 to 28 weeks. We also found a significant increase in perinatal mortality, mainly due to infection, when the latent phase was prolonged for >7 days, regardless of the type of management.

Original languageEnglish (US)
Pages (from-to)1059-1063
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume154
Issue number5
DOIs
StatePublished - Jan 1 1986

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Retrospective Studies
Steroids
Perinatal Mortality
Birth Weight
Glucocorticoids
Gestational Age
Tocolytic Agents
Hyaline Membrane Disease
Therapeutics
Pregnancy Outcome
Rupture
Adrenal Cortex Hormones
Mothers
Weights and Measures
Membranes
Preterm Premature Rupture of the Membranes
Incidence
Infection

Keywords

  • Fetal membranes
  • corticosteroids
  • hyaline membrane disease
  • premature rupture

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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