A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

Andrew T Dudley, Karen M. Lyons, Elizabeth J. Robertson

Research output: Contribution to journalArticle

892 Citations (Scopus)

Abstract

BMP-7/OP-1, a member of the transforming growth factor-β (TGF-β) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.

Original languageEnglish (US)
Pages (from-to)2795-2807
Number of pages13
JournalGenes and Development
Volume9
Issue number22
DOIs
StatePublished - Nov 15 1995

Fingerprint

Bone Morphogenetic Protein 7
Kidney
Anophthalmos
Transforming Growth Factors
Growth and Development
Embryonic Development
Intercellular Signaling Peptides and Proteins
Parturition

Keywords

  • Bone morphogenetic proteins
  • TGF-β growth factors
  • eye development
  • gene targeting
  • kidney development

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. / Dudley, Andrew T; Lyons, Karen M.; Robertson, Elizabeth J.

In: Genes and Development, Vol. 9, No. 22, 15.11.1995, p. 2795-2807.

Research output: Contribution to journalArticle

Dudley, Andrew T ; Lyons, Karen M. ; Robertson, Elizabeth J. / A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. In: Genes and Development. 1995 ; Vol. 9, No. 22. pp. 2795-2807.
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