A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

Andrew T. Dudley, Karen M. Lyons, Elizabeth J. Robertson

Research output: Contribution to journalArticle

906 Scopus citations

Abstract

BMP-7/OP-1, a member of the transforming growth factor-β (TGF-β) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.

Original languageEnglish (US)
Pages (from-to)2795-2807
Number of pages13
JournalGenes and Development
Volume9
Issue number22
DOIs
StatePublished - Nov 15 1995

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Keywords

  • Bone morphogenetic proteins
  • TGF-β growth factors
  • eye development
  • gene targeting
  • kidney development

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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