A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy

Amy J Hoffman, Ruth Ann Brintnall, Alexander von Eye, Lee W. Jones, Gordon Alderink, Lawrence H. Patzelt, Jean K. Brown

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy. Materials and methods: Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy. Results: Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels. Conclusion: The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted.

Original languageEnglish (US)
Pages (from-to)415-423
Number of pages9
JournalOncoTargets and Therapy
Volume7
DOIs
StatePublished - Mar 10 2014

Fingerprint

Lung Neoplasms
Rehabilitation
Exercise
Drug Therapy
Fatigue
Quality of Life
Thoracotomy
Non-Small Cell Lung Carcinoma
Neoplasms
Equipment and Supplies
Adjuvant Chemotherapy
Radiotherapy
Randomized Controlled Trials
Outcome Assessment (Health Care)
Light

Keywords

  • Cancer-related fatigue
  • Exercise
  • Functional status
  • Lung cancer
  • Quality of life
  • Symptoms

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Hoffman, A. J., Brintnall, R. A., von Eye, A., Jones, L. W., Alderink, G., Patzelt, L. H., & Brown, J. K. (2014). A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy. OncoTargets and Therapy, 7, 415-423. https://doi.org/10.2147/OTT.S57262

A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy. / Hoffman, Amy J; Brintnall, Ruth Ann; von Eye, Alexander; Jones, Lee W.; Alderink, Gordon; Patzelt, Lawrence H.; Brown, Jean K.

In: OncoTargets and Therapy, Vol. 7, 10.03.2014, p. 415-423.

Research output: Contribution to journalArticle

Hoffman, AJ, Brintnall, RA, von Eye, A, Jones, LW, Alderink, G, Patzelt, LH & Brown, JK 2014, 'A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy', OncoTargets and Therapy, vol. 7, pp. 415-423. https://doi.org/10.2147/OTT.S57262
Hoffman, Amy J ; Brintnall, Ruth Ann ; von Eye, Alexander ; Jones, Lee W. ; Alderink, Gordon ; Patzelt, Lawrence H. ; Brown, Jean K. / A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy. In: OncoTargets and Therapy. 2014 ; Vol. 7. pp. 415-423.
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abstract = "Objective: The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy. Materials and methods: Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy. Results: Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels. Conclusion: The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted.",
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