A red Cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide

Haishi Cao, Yijia Xiong, Ting Wang, Baowei Chen, Thomas C. Squier, M. Uljana Mayer

Research output: Contribution to journalArticle

Abstract

We have synthesized a red biarsenical fluorescent probe, AsCy3, with good photostability, low pH sensitivity, high absorbance, and good quantum yield. It is directed specifically to a small tetracysteine peptide binding motif, Cy3TAG (CysCysLysAlaGluAlaAlaCysCys), in the presence of other tetracysteine tags. This new probe provides a FRET partner to biarsenical dye FlAsH, making this discovery an important step toward a whole toolkit of colored probes directed to different small peptide motifs.

Original languageEnglish (US)
Pages (from-to)8672-8673
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number28
DOIs
StatePublished - Jul 18 2007

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Fluorescent Dyes
Peptides
Quantum yield
Coloring Agents
Dyes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

A red Cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide. / Cao, Haishi; Xiong, Yijia; Wang, Ting; Chen, Baowei; Squier, Thomas C.; Mayer, M. Uljana.

In: Journal of the American Chemical Society, Vol. 129, No. 28, 18.07.2007, p. 8672-8673.

Research output: Contribution to journalArticle

Cao, Haishi ; Xiong, Yijia ; Wang, Ting ; Chen, Baowei ; Squier, Thomas C. ; Mayer, M. Uljana. / A red Cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide. In: Journal of the American Chemical Society. 2007 ; Vol. 129, No. 28. pp. 8672-8673.
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