A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

Zhen Kun Pan, Georgios Ikonomidis, Audrey Lazenby, Drew Pardoll, Yvonne Paterson

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Abstract

Listeria monocytogenes is an intracellular organism that has the unusual ability to live in the cytoplasm of the cell. It is thus a good vector for targeting protein antigens to the cellular arm of the immune response. Here we use a model system, consisting of colon and renal carcinomas that express the influenza virus nucleoprotein and a recombinant L. monocytogenes that secretes this antigen, to test the potential of this organism as a cancer immunotherapeutic agent. We show that this recombinant organism can not only protect mice against lethal challenge with tumour cells that express the antigen, but can also cause regression of established macroscopic tumours in an antigen-specific T-cell-dependent manner.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalNature Medicine
Volume1
Issue number5
DOIs
StatePublished - May 1995

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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