A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival

Yue Wang, David Pot, Stephen D. Kachman, Sergey V. Nuzhdin, Lawrence G. Harshman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.

Original languageEnglish (US)
Pages (from-to)355-366
Number of pages12
JournalJournal of Heredity
Volume97
Issue number4
DOIs
StatePublished - Jul 1 2006

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Quantitative Trait Loci
Drosophila melanogaster
quantitative trait loci
Oxidative Stress
oxidative stress
genetic variation
inbred lines
Ovum
egg production
autosomes
life history
Genome
Oxygen
oxygen
genome
gender
Population

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival. / Wang, Yue; Pot, David; Kachman, Stephen D.; Nuzhdin, Sergey V.; Harshman, Lawrence G.

In: Journal of Heredity, Vol. 97, No. 4, 01.07.2006, p. 355-366.

Research output: Contribution to journalArticle

Wang, Yue ; Pot, David ; Kachman, Stephen D. ; Nuzhdin, Sergey V. ; Harshman, Lawrence G. / A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival. In: Journal of Heredity. 2006 ; Vol. 97, No. 4. pp. 355-366.
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