A quantitative evaluation of magnetic resonance image signal changes of the brain in chronic hepatic encephalopathy

Neil S. Norton, James R. McConnell, Rowen K Zetterman, Jorge F. Rodriguez-Sierra

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hyperintensity in the basal ganglia of patients with serious liver disease is a common finding on T1-weighted magnetic resonance images. In this study, we used optical densitometry to quantitatively evaluate the hyperintense magnetic resonance image signal changes in the various regions of the brain of patients with chronic hepatic encephalopathy. The incidence and morphological distribution of the magnetic resonance signal changes were evaluated from T1-weighted magnetic resonance images of the brain from seven non-alcoholic patients and six healthy controls. Significant differences (p<0.05) between the patient group and controls were found in the limbic system (hippocampus, temporal lobe, cingulate gyrus, and fornix), extrapyramidal system and associated myelinated pathways (lentiform nucleus, tectum, tegmentum, cerebral peduncles, internal capsule and the corpus callosum). No measurable differences were observed in the frontal, parietal, and occipital cortex, or the dorsomedial thalamus. The presence of the high signal intensity changes on T1-weighted magnetic resonance image suggests that characteristic alterations occur in functional regions of the brain in chronic hepatic encephalopathy.

Original languageEnglish (US)
Pages (from-to)764-770
Number of pages7
JournalJournal of Hepatology
Volume21
Issue number5
DOIs
StatePublished - 1994

Fingerprint

Chronic Brain Damage
Hepatic Encephalopathy
Magnetic Resonance Spectroscopy
Brain
Internal Capsule
Corpus Striatum
Occipital Lobe
Limbic System
Parietal Lobe
Densitometry
Corpus Callosum
Gyrus Cinguli
Frontal Lobe
Temporal Lobe
Basal Ganglia
Thalamus
Liver Diseases
Hippocampus
Control Groups
Incidence

Keywords

  • Basal ganglia
  • Hepatic encephalopathy
  • Image analysis
  • Limbic system
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Hepatology

Cite this

A quantitative evaluation of magnetic resonance image signal changes of the brain in chronic hepatic encephalopathy. / Norton, Neil S.; McConnell, James R.; Zetterman, Rowen K; Rodriguez-Sierra, Jorge F.

In: Journal of Hepatology, Vol. 21, No. 5, 1994, p. 764-770.

Research output: Contribution to journalArticle

Norton, Neil S. ; McConnell, James R. ; Zetterman, Rowen K ; Rodriguez-Sierra, Jorge F. / A quantitative evaluation of magnetic resonance image signal changes of the brain in chronic hepatic encephalopathy. In: Journal of Hepatology. 1994 ; Vol. 21, No. 5. pp. 764-770.
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