A quantitative analysis of the reward-enhancing effects of nicotine using reinforcer demand

Scott T. Barrett, Rick A Bevins

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Reward enhancement by nicotine has been suggested as an important phenomenon contributing toward tobacco abuse and dependence. Reinforcement value is a multifaceted construct not fully represented by any single measure of response strength. The present study evaluated the changes in the reinforcement value of a visual stimulus in 16 male Sprague-Dawley rats using the reinforcer demand technique proposed by Hursh and Silberberg. The different parameters of the model have been shown to represent differing facets of reinforcement value, including intensity, perseverance, and sensitivity to changes in response cost. Rats lever-pressed for 1-min presentations of a compound visual stimulus over blocks of 10 sessions across a range of response requirements (fixed ratio 1, 2, 4, 8, 14, 22, 32). Nicotine (0.4 mg/kg, base) or saline was administered 5 min before each session. Estimates from the demand model were calculated between nicotine and saline administration conditions within subjects and changes in reinforcement value were assessed as differences in Q0, Pmax, Omax, and essential value. Nicotine administration increased operant responding across the entire range of reinforcement schedules tested, and uniformly affected model parameter estimates in a manner suggesting increased reinforcement value of the visual stimulus.

Original languageEnglish (US)
Pages (from-to)781-789
Number of pages9
JournalBehavioural pharmacology
Volume23
Issue number8
DOIs
StatePublished - Dec 1 2012

Fingerprint

Nicotine
Reward
Reinforcement Schedule
Tobacco Use Disorder
Sprague Dawley Rats
Reinforcement (Psychology)
Costs and Cost Analysis

Keywords

  • nicotine
  • rat
  • reinforcer demand
  • reward

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

A quantitative analysis of the reward-enhancing effects of nicotine using reinforcer demand. / Barrett, Scott T.; Bevins, Rick A.

In: Behavioural pharmacology, Vol. 23, No. 8, 01.12.2012, p. 781-789.

Research output: Contribution to journalArticle

@article{3107641adc5d4e80be3b0dae4b310878,
title = "A quantitative analysis of the reward-enhancing effects of nicotine using reinforcer demand",
abstract = "Reward enhancement by nicotine has been suggested as an important phenomenon contributing toward tobacco abuse and dependence. Reinforcement value is a multifaceted construct not fully represented by any single measure of response strength. The present study evaluated the changes in the reinforcement value of a visual stimulus in 16 male Sprague-Dawley rats using the reinforcer demand technique proposed by Hursh and Silberberg. The different parameters of the model have been shown to represent differing facets of reinforcement value, including intensity, perseverance, and sensitivity to changes in response cost. Rats lever-pressed for 1-min presentations of a compound visual stimulus over blocks of 10 sessions across a range of response requirements (fixed ratio 1, 2, 4, 8, 14, 22, 32). Nicotine (0.4 mg/kg, base) or saline was administered 5 min before each session. Estimates from the demand model were calculated between nicotine and saline administration conditions within subjects and changes in reinforcement value were assessed as differences in Q0, Pmax, Omax, and essential value. Nicotine administration increased operant responding across the entire range of reinforcement schedules tested, and uniformly affected model parameter estimates in a manner suggesting increased reinforcement value of the visual stimulus.",
keywords = "nicotine, rat, reinforcer demand, reward",
author = "Barrett, {Scott T.} and Bevins, {Rick A}",
year = "2012",
month = "12",
day = "1",
doi = "10.1097/FBP.0b013e32835a38d9",
language = "English (US)",
volume = "23",
pages = "781--789",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - A quantitative analysis of the reward-enhancing effects of nicotine using reinforcer demand

AU - Barrett, Scott T.

AU - Bevins, Rick A

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Reward enhancement by nicotine has been suggested as an important phenomenon contributing toward tobacco abuse and dependence. Reinforcement value is a multifaceted construct not fully represented by any single measure of response strength. The present study evaluated the changes in the reinforcement value of a visual stimulus in 16 male Sprague-Dawley rats using the reinforcer demand technique proposed by Hursh and Silberberg. The different parameters of the model have been shown to represent differing facets of reinforcement value, including intensity, perseverance, and sensitivity to changes in response cost. Rats lever-pressed for 1-min presentations of a compound visual stimulus over blocks of 10 sessions across a range of response requirements (fixed ratio 1, 2, 4, 8, 14, 22, 32). Nicotine (0.4 mg/kg, base) or saline was administered 5 min before each session. Estimates from the demand model were calculated between nicotine and saline administration conditions within subjects and changes in reinforcement value were assessed as differences in Q0, Pmax, Omax, and essential value. Nicotine administration increased operant responding across the entire range of reinforcement schedules tested, and uniformly affected model parameter estimates in a manner suggesting increased reinforcement value of the visual stimulus.

AB - Reward enhancement by nicotine has been suggested as an important phenomenon contributing toward tobacco abuse and dependence. Reinforcement value is a multifaceted construct not fully represented by any single measure of response strength. The present study evaluated the changes in the reinforcement value of a visual stimulus in 16 male Sprague-Dawley rats using the reinforcer demand technique proposed by Hursh and Silberberg. The different parameters of the model have been shown to represent differing facets of reinforcement value, including intensity, perseverance, and sensitivity to changes in response cost. Rats lever-pressed for 1-min presentations of a compound visual stimulus over blocks of 10 sessions across a range of response requirements (fixed ratio 1, 2, 4, 8, 14, 22, 32). Nicotine (0.4 mg/kg, base) or saline was administered 5 min before each session. Estimates from the demand model were calculated between nicotine and saline administration conditions within subjects and changes in reinforcement value were assessed as differences in Q0, Pmax, Omax, and essential value. Nicotine administration increased operant responding across the entire range of reinforcement schedules tested, and uniformly affected model parameter estimates in a manner suggesting increased reinforcement value of the visual stimulus.

KW - nicotine

KW - rat

KW - reinforcer demand

KW - reward

UR - http://www.scopus.com/inward/record.url?scp=84870062215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870062215&partnerID=8YFLogxK

U2 - 10.1097/FBP.0b013e32835a38d9

DO - 10.1097/FBP.0b013e32835a38d9

M3 - Article

C2 - 23080311

AN - SCOPUS:84870062215

VL - 23

SP - 781

EP - 789

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 8

ER -