A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M-1 s-1. It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry