A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma

P. Satwani, K. W. Ahn, J. Carreras, H. Abdel-Azim, M. S. Cairo, A. Cashen, A. I. Chen, J. B. Cohen, L. J. Costa, C. Dandoy, T. S. Fenske, C. O. Freytes, S. Ganguly, R. P. Gale, N. Ghosh, M. S. Hertzberg, R. J. Hayashi, R. T. Kamble, A. S. Kanate, A. KeatingM. A. Kharfan-Dabaja, H. M. Lazarus, D. I. Marks, T. Nishihori, R. F. Olsson, T. D. Prestidge, J. M. Rolon, B. N. Savani, Julie Marie Vose, W. A. Wood, D. J. Inwards, V. Bachanova, S. M. Smith, D. G. Maloney, A. Sureda, M. Hamadani

Research output: Contribution to journalArticle

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Abstract

Autologous hematopoietic cell transplantation (AutoHCT) is a potentially curative treatment modality for relapsed/refractory Hodgkin lymphoma (HL). However, no large studies have evaluated pretransplant factors predictive of outcomes of AutoHCT in children, adolescents and young adults (CAYA, age <30 years). In a retrospective study, we analyzed 606 CAYA patients (median age 23 years) with relapsed/refractory HL who underwent AutoHCT between 1995 and 2010. The probabilities of PFS at 1, 5 and 10 years were 66% (95% confidence interval (CI): 62-70), 52% (95% CI: 48-57) and 47% (95% CI: 42-51), respectively. Multivariate analysis for PFS demonstrated that at the time of AutoHCT patients with Karnofsky/Lansky score ≥90, no extranodal involvement and chemosensitive disease had significantly improved PFS. Patients with time from diagnosis to first relapse of <1 year had a significantly inferior PFS. A prognostic model for PFS was developed that stratified patients into low-, intermediate- and high-risk groups, predicting for 5-year PFS probabilities of 72% (95% CI: 64-80), 53% (95% CI: 47-59) and 23% (95% CI: 9-36), respectively. This large study identifies a group of CAYA patients with relapsed/refractory HL who are at high risk of progression after AutoHCT. Such patients should be targeted for novel therapeutic and/or maintenance approaches post-AutoHCT.

Original languageEnglish (US)
Pages (from-to)1416-1423
Number of pages8
JournalBone marrow transplantation
Volume50
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Autologous Transplantation
Cell Transplantation
Hodgkin Disease
Young Adult
Confidence Intervals
Multivariate Analysis
Retrospective Studies
Maintenance
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Satwani, P., Ahn, K. W., Carreras, J., Abdel-Azim, H., Cairo, M. S., Cashen, A., ... Hamadani, M. (2015). A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma. Bone marrow transplantation, 50(11), 1416-1423. https://doi.org/10.1038/bmt.2015.177

A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma. / Satwani, P.; Ahn, K. W.; Carreras, J.; Abdel-Azim, H.; Cairo, M. S.; Cashen, A.; Chen, A. I.; Cohen, J. B.; Costa, L. J.; Dandoy, C.; Fenske, T. S.; Freytes, C. O.; Ganguly, S.; Gale, R. P.; Ghosh, N.; Hertzberg, M. S.; Hayashi, R. J.; Kamble, R. T.; Kanate, A. S.; Keating, A.; Kharfan-Dabaja, M. A.; Lazarus, H. M.; Marks, D. I.; Nishihori, T.; Olsson, R. F.; Prestidge, T. D.; Rolon, J. M.; Savani, B. N.; Vose, Julie Marie; Wood, W. A.; Inwards, D. J.; Bachanova, V.; Smith, S. M.; Maloney, D. G.; Sureda, A.; Hamadani, M.

In: Bone marrow transplantation, Vol. 50, No. 11, 01.11.2015, p. 1416-1423.

Research output: Contribution to journalArticle

Satwani, P, Ahn, KW, Carreras, J, Abdel-Azim, H, Cairo, MS, Cashen, A, Chen, AI, Cohen, JB, Costa, LJ, Dandoy, C, Fenske, TS, Freytes, CO, Ganguly, S, Gale, RP, Ghosh, N, Hertzberg, MS, Hayashi, RJ, Kamble, RT, Kanate, AS, Keating, A, Kharfan-Dabaja, MA, Lazarus, HM, Marks, DI, Nishihori, T, Olsson, RF, Prestidge, TD, Rolon, JM, Savani, BN, Vose, JM, Wood, WA, Inwards, DJ, Bachanova, V, Smith, SM, Maloney, DG, Sureda, A & Hamadani, M 2015, 'A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma', Bone marrow transplantation, vol. 50, no. 11, pp. 1416-1423. https://doi.org/10.1038/bmt.2015.177
Satwani, P. ; Ahn, K. W. ; Carreras, J. ; Abdel-Azim, H. ; Cairo, M. S. ; Cashen, A. ; Chen, A. I. ; Cohen, J. B. ; Costa, L. J. ; Dandoy, C. ; Fenske, T. S. ; Freytes, C. O. ; Ganguly, S. ; Gale, R. P. ; Ghosh, N. ; Hertzberg, M. S. ; Hayashi, R. J. ; Kamble, R. T. ; Kanate, A. S. ; Keating, A. ; Kharfan-Dabaja, M. A. ; Lazarus, H. M. ; Marks, D. I. ; Nishihori, T. ; Olsson, R. F. ; Prestidge, T. D. ; Rolon, J. M. ; Savani, B. N. ; Vose, Julie Marie ; Wood, W. A. ; Inwards, D. J. ; Bachanova, V. ; Smith, S. M. ; Maloney, D. G. ; Sureda, A. ; Hamadani, M. / A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma. In: Bone marrow transplantation. 2015 ; Vol. 50, No. 11. pp. 1416-1423.
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abstract = "Autologous hematopoietic cell transplantation (AutoHCT) is a potentially curative treatment modality for relapsed/refractory Hodgkin lymphoma (HL). However, no large studies have evaluated pretransplant factors predictive of outcomes of AutoHCT in children, adolescents and young adults (CAYA, age <30 years). In a retrospective study, we analyzed 606 CAYA patients (median age 23 years) with relapsed/refractory HL who underwent AutoHCT between 1995 and 2010. The probabilities of PFS at 1, 5 and 10 years were 66{\%} (95{\%} confidence interval (CI): 62-70), 52{\%} (95{\%} CI: 48-57) and 47{\%} (95{\%} CI: 42-51), respectively. Multivariate analysis for PFS demonstrated that at the time of AutoHCT patients with Karnofsky/Lansky score ≥90, no extranodal involvement and chemosensitive disease had significantly improved PFS. Patients with time from diagnosis to first relapse of <1 year had a significantly inferior PFS. A prognostic model for PFS was developed that stratified patients into low-, intermediate- and high-risk groups, predicting for 5-year PFS probabilities of 72{\%} (95{\%} CI: 64-80), 53{\%} (95{\%} CI: 47-59) and 23{\%} (95{\%} CI: 9-36), respectively. This large study identifies a group of CAYA patients with relapsed/refractory HL who are at high risk of progression after AutoHCT. Such patients should be targeted for novel therapeutic and/or maintenance approaches post-AutoHCT.",
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AU - Satwani, P.

AU - Ahn, K. W.

AU - Carreras, J.

AU - Abdel-Azim, H.

AU - Cairo, M. S.

AU - Cashen, A.

AU - Chen, A. I.

AU - Cohen, J. B.

AU - Costa, L. J.

AU - Dandoy, C.

AU - Fenske, T. S.

AU - Freytes, C. O.

AU - Ganguly, S.

AU - Gale, R. P.

AU - Ghosh, N.

AU - Hertzberg, M. S.

AU - Hayashi, R. J.

AU - Kamble, R. T.

AU - Kanate, A. S.

AU - Keating, A.

AU - Kharfan-Dabaja, M. A.

AU - Lazarus, H. M.

AU - Marks, D. I.

AU - Nishihori, T.

AU - Olsson, R. F.

AU - Prestidge, T. D.

AU - Rolon, J. M.

AU - Savani, B. N.

AU - Vose, Julie Marie

AU - Wood, W. A.

AU - Inwards, D. J.

AU - Bachanova, V.

AU - Smith, S. M.

AU - Maloney, D. G.

AU - Sureda, A.

AU - Hamadani, M.

PY - 2015/11/1

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N2 - Autologous hematopoietic cell transplantation (AutoHCT) is a potentially curative treatment modality for relapsed/refractory Hodgkin lymphoma (HL). However, no large studies have evaluated pretransplant factors predictive of outcomes of AutoHCT in children, adolescents and young adults (CAYA, age <30 years). In a retrospective study, we analyzed 606 CAYA patients (median age 23 years) with relapsed/refractory HL who underwent AutoHCT between 1995 and 2010. The probabilities of PFS at 1, 5 and 10 years were 66% (95% confidence interval (CI): 62-70), 52% (95% CI: 48-57) and 47% (95% CI: 42-51), respectively. Multivariate analysis for PFS demonstrated that at the time of AutoHCT patients with Karnofsky/Lansky score ≥90, no extranodal involvement and chemosensitive disease had significantly improved PFS. Patients with time from diagnosis to first relapse of <1 year had a significantly inferior PFS. A prognostic model for PFS was developed that stratified patients into low-, intermediate- and high-risk groups, predicting for 5-year PFS probabilities of 72% (95% CI: 64-80), 53% (95% CI: 47-59) and 23% (95% CI: 9-36), respectively. This large study identifies a group of CAYA patients with relapsed/refractory HL who are at high risk of progression after AutoHCT. Such patients should be targeted for novel therapeutic and/or maintenance approaches post-AutoHCT.

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