A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

M. R. Fernando, S. M.D.Nalinie Wickramasinghe, M. Ira Thabrew, E. H. Karunanayaka

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of Ethnopharmacology
Volume27
Issue number1-2
DOIs
StatePublished - Nov 1989

Fingerprint

Hypoglycemic Agents
Blood Glucose
Fasting
Glucose
Sri Lanka
Tolbutamide
Plant Extracts
Sprague Dawley Rats
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Fernando, M. R., Wickramasinghe, S. M. D. N., Thabrew, M. I., & Karunanayaka, E. H. (1989). A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia. Journal of Ethnopharmacology, 27(1-2), 7-14. https://doi.org/10.1016/0378-8741(89)90072-X

A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia. / Fernando, M. R.; Wickramasinghe, S. M.D.Nalinie; Thabrew, M. Ira; Karunanayaka, E. H.

In: Journal of Ethnopharmacology, Vol. 27, No. 1-2, 11.1989, p. 7-14.

Research output: Contribution to journalArticle

Fernando, M. R. ; Wickramasinghe, S. M.D.Nalinie ; Thabrew, M. Ira ; Karunanayaka, E. H. / A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia. In: Journal of Ethnopharmacology. 1989 ; Vol. 27, No. 1-2. pp. 7-14.
@article{4d0b149604de41878abd778b02c54dd9,
title = "A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia",
abstract = "Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.",
author = "Fernando, {M. R.} and Wickramasinghe, {S. M.D.Nalinie} and Thabrew, {M. Ira} and Karunanayaka, {E. H.}",
year = "1989",
month = "11",
doi = "10.1016/0378-8741(89)90072-X",
language = "English (US)",
volume = "27",
pages = "7--14",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

AU - Fernando, M. R.

AU - Wickramasinghe, S. M.D.Nalinie

AU - Thabrew, M. Ira

AU - Karunanayaka, E. H.

PY - 1989/11

Y1 - 1989/11

N2 - Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

AB - Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

UR - http://www.scopus.com/inward/record.url?scp=0024852346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024852346&partnerID=8YFLogxK

U2 - 10.1016/0378-8741(89)90072-X

DO - 10.1016/0378-8741(89)90072-X

M3 - Article

C2 - 2615428

AN - SCOPUS:0024852346

VL - 27

SP - 7

EP - 14

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 1-2

ER -