A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents

Philip P. Vickers, Robert B. Dixon, Kenneth H Cowan

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.

Original languageEnglish (US)
Pages (from-to)443-445
Number of pages3
JournalTrends in Pharmacological Sciences
Volume9
Issue number12
DOIs
StatePublished - Jan 1 1988

Fingerprint

Hormonal Antineoplastic Agents
Estrogen Receptor Modulators
Epidermal Growth Factor Receptor
Estrogen Receptors
Carcinogens
Estrogens
Cells
Pumps
Breast Neoplasms
Pharmaceutical Preparations
Cell Line

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents. / Vickers, Philip P.; Dixon, Robert B.; Cowan, Kenneth H.

In: Trends in Pharmacological Sciences, Vol. 9, No. 12, 01.01.1988, p. 443-445.

Research output: Contribution to journalReview article

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