A pilot study of soluble adhesion molecules as surrogate markers for acute liver allograft rejection

Victor J. Navarro, David Silver, Alan Norman Langnas, Rodney Smith Markin, Amy L. Friedman, Jordan S. Pober

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Tissue endothelial adhesion molecule expression is increased during acute liver allograft rejection. Soluble forms exist, but their correlation to rejection and their clinical value have not been determined. Methods. We studied endothelial adhesion molecule tissue expression and soluble levels in blood and bile and correlated these to the clinical course of 11 adult patients followed for 30 consecutive days after liver transplantation. Results. Three biopsies showing acute rejection demonstrated increased intercellular adhesion molecule (ICAM)-1 but not endothelial leukocyte adhesion molecule-1 expression on hepatic endothelial cells during rejection. Vascular cell adhesion molecule (VCAM)-1 staining was focally increased in two of three specimens. Levels of soluble ICAM-1 or soluble VCAM-1 by ELISA did not distinguish acute rejection from nonrejection conditions. Conclusion. We confirmed that endothelial ICAM-1 expression is more intense in rejecting allografts and is more sensitive than changes in VCAM-1 or endothelial leukocyte adhesion molecule-1. However, soluble adhesion molecule determination was not useful in the accurate detection of acute rejection.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalTransplantation
Volume65
Issue number1
DOIs
StatePublished - Jan 15 1998

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Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Tissue Adhesions
Allografts
E-Selectin
Biomarkers
Liver
Bile
Liver Transplantation
Hepatocytes
Endothelial Cells
Enzyme-Linked Immunosorbent Assay
Staining and Labeling
Biopsy

ASJC Scopus subject areas

  • Transplantation

Cite this

A pilot study of soluble adhesion molecules as surrogate markers for acute liver allograft rejection. / Navarro, Victor J.; Silver, David; Langnas, Alan Norman; Markin, Rodney Smith; Friedman, Amy L.; Pober, Jordan S.

In: Transplantation, Vol. 65, No. 1, 15.01.1998, p. 126-129.

Research output: Contribution to journalArticle

Navarro, Victor J. ; Silver, David ; Langnas, Alan Norman ; Markin, Rodney Smith ; Friedman, Amy L. ; Pober, Jordan S. / A pilot study of soluble adhesion molecules as surrogate markers for acute liver allograft rejection. In: Transplantation. 1998 ; Vol. 65, No. 1. pp. 126-129.
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AU - Pober, Jordan S.

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